Zerodol

Rheumatoid Arthritis man

Therapeutic Indications

Zedorol is a Non-Steroid Anti-Inflammatory Drug (NSAID). Zerodol is used for management and relief of pain ranging from mild to moderate and inflammations. It also has analgesic properties. Zerodol is a brand name for Aceclofenac. Zerodol exists as tablets, injection, and capsules. It is used in the management of the following conditions:

  • Rheumatoid Arthritis manRheumatoid arthritis
  • Osteoarthritis
  • Ankylosing spondylitis
  • Pain
  • Arthritis
  • Periarthritis of the scapulohumeral (frozen shoulder)
  • Back pain
  • Ischiadynia
  • Headache
  • Fever
  • Tooth pain
  • Myalgia
  • Arthralgia
  • Menstruation pain
  • Post-operative pain
  • Gout

Do I Need a Prescription?

Zerodol tablets are available in pharmacies close to you and can also be bought from online drug stores. But a doctor’s prescription is mandatory.

Dosage

The dosage for Zerodol depends on the age, weight, the condition of your kidney and liver, other medications you are using, the condition being treated and the response to the medication. The recommended dosage for Zerodal is – 100 mg taken two times a day. In some cases, it is taken once a day as 200 mg.

Chemical composition

The active ingredient in Zerodol tablets is:

  • 100 mg Aceclofenac

Zerodol injection has:

  • 150 mg Aceclofenac

Mechanism of Action (MOA)

The active ingredient Aceclofenac has both analgesic and anti-Osteoarthritis kneeinflammatory effects. It is a non-steroid agent. Aceclofenac works by preventing the production of prostaglandins by inhibiting the enzyme cyclooxygenase that is used in their production. Prostaglandins are chemicals produced by the body in the event of injuries, due to some diseases and conditions. Prostaglandins cause pain, inflammation, and swelling. When their production is halted, it reduces pain and inflammation. It also has anti-pyretic properties, thus reduces fever. The production of glycosaminoglycans(GAG) is increased with the use of Zerodol. GAG is utilized in the repair and regeneration of articular cartilage, relieving on symptoms of arthritis.

Contraindications

Zerodol is not recommended for use in some conditions. When used it could worsen the existing medical condition or increase the chances of adverse reactions occurring. Inform your doctor of any medical conditions you have or have had previously as they could affect the prescription. The following conditions are contraindicated:

  • Allergic reaction to Aceclofenac: Do not use Zerodol if you have an allergic reaction to the active ingredient or to other NSAIDs
  • A peptic ulcer that is active
  • Acute rhinitis
  • Urticaria
  • Asthma
  • Severe renal impairment
  • Severe liver disease
  • Heart attack history
  • Bleeding disorder: Zerodol can lead to swelling and bleeding occurring in the stomach, colon, and anus
  • Planned surgery or dental procedure
  • Pregnant or planning to be pregnant: Zerodol use when you are trying to conceive is not recommended as it may affect fertility. If you are pregnant especially in the third trimester, the use of Zerodol could harm the developing fetus as it can cause kidney failure in the fetus, heart abnormalities and even the loss of the pregnancy.
  • Diarrhea
  • High blood pressure
  • Diabetes
  • High levels of cholesterol
  • Chickenpox or shingles that keep reoccurring
  • An immune system that is overactive
  • There is an increased chance of side effects.
  • Crohn’s disease
  • Zerodol might cause brain and spinal cord inflammation(aseptic meningitis)

It should be used with caution when the benefits outweigh the risks.

Facts on Zerodol

  • It takes about 1.5 to 3 hours for the results of Zerodol to be noticed once administered.
  • The effects of Zerodol can last for an average duration of 12 to 16 hours.
  • Peak concentrations of Zerodol in plasma occurs after 1-3 hours.
  • Zerodol is 99% transported by binding to proteins.
  • Zerodol is excreted through urine once it is metabolized to hydroxy metabolites with an elimination half-life of 4 hours.
  • Zerodol use should be avoided in the third trimester of pregnancy as it has been shown to harm the developing fetus.

 

Side effects

lower back painZerodol can cause an adverse reaction apart from the intended effects. The side effects do not occur in every individual. They depend on the dosage, duration of use, underlying medical conditions and individual response to the medication. The side effects can be common and less serious while others can be rare and very serious. Report to your doctor any side effects you might experience especially if they do not go away. Most of the side effects are reversible. The common side effects include:

  • Diarrhea
  • Abdominal pain
  • Dyspepsia
  • Nausea
  • Dizziness
  • Drowsiness
  • Indigestion
  • The elderly might experience gastrointestinal bleeding and perforation, rupturing of the bowel and develop stomach ulcers.
  • Heartburn

Rare side effects include:

  • Rash
  • Pruritus
  • Abnormal liver enzymes
  • Increased serum creatinine
  • Severe Gastrointestinal bleeding
  • Blood dyscrasias
  • Nephrotoxicity
  • Fluid retention
  • Constipation
  • Stools being black
  • Leg cramps
  • Abnormal dreams
  • Tingling, numbness, prickling and chilling sensation on the skin
  • Reduced production of white blood cells, immunity cells, and platelets.
  • Lower taste sensitivity
  • Increased levels of blood urea, alkaline phosphate, and creatinine
  • Jaundice
  • Ulceration of the mouth
  • Palpitations
  • Ear ringing
  • Vomiting blood
  • Tremors
  • Visual disturbances
  • Sleeplessness
  • Loss of skin outer layer and mucosal layer( Stevens-Johnson Syndrome)
  • Bronchospasms
  • Ulcerative colitis
  • Blood clots
  • Heart attack

If you experience an allergic reaction to Zerodol and symptoms of Stevens-Johnson syndrome, immediately stop using the medication and seek medicals attention. Signs of an allergic reaction include:

  • Rashes
  • Swelling of the face, throat, tongue, and lips.
  • Difficulties breathing

In case you accidentally take an overdose of Zerodol, report to your doctor or immediately rush into the emergency center of the nearest hospital taking the package with you for identification. Taking an overdose can result in toxicity. Symptoms of Zerodol overdose include:

  • Gastric pain
  • Gastrointestinal bleeding
  • Drowsiness
  • Dizziness
  • Headache
  • Failure of the kidneys
  • Damage to the liver
  • A drop in the blood pressure
  • Nausea
  • Vomiting
  • Ringing in the ears

Drug interactions

Taking more than two drugs at the same time can result in drug interactions. Drug interactions can lead to adverse effects occurring or interfere with the working of your medication. Inform your doctor of all medications you are using, both over the counter and prescriptions drugs, dietary supplements and herbal products. The following drugs and products interact with Zerodol:

  • When used together, Zerodol affects blood sugar levels thus they should be monitored closely.
  • When used together it leads to an increase in Digoxin levels and their effects.
  • Can result in kidney damage when used concurrently with Zerodol.
  • It increases the levels of lithium that can cause adverse reactions
  • Ibuprofen
  • Warfarin
  • Concurrent use increases the chances of gastrointestinal bleeding
  • Cyclosporin
  • Tacrolimus
  • Estrogen
  • Methotrexate
  • Plicamycin
  • Procarbazine
  • Temozolomide
  • It increases bleeding in the stomach
  • Cardiac glycosides increase the risk of heart failure.
  • Zerodol reduces its effects thus its use should be avoided for at least 8-12 days after taking mifepristone.
  • Concurrent use increases anticoagulation activity.
  • Potassium-sparing diuretics
  • ACE inhibitors
  • Quinolones increase the occurrence of fainting

What to Do If You Skip a Dose

If you skip a dose, immediately take it when you realize it. If it is close to the time for your next dose, you can skip the dose and take the next scheduled dose then continue with your normal routine. Do not double the dose to compensate for the skipped dose. Avoid missing doses as it makes the medication to be less effective. Set a reminder or have a family member remind you when it is time for your next dose.

Precautions

A number of precautions should be considered before you use Zerodol. The precautions include:

  • Allergic or hypersensitive reactions. Do not sue Zerodol if you are allergic to the active ingredient or other NSAIDs.
  • Have renal impairment. It should be used with caution, dose adjustment is recommended as Zerodol can cause damage to the kidneys when used for a long duration.
  • Hepatic impairment or diseases. It increases the chances of side effects like jaundice, dose adjustment is recommended.
  • Pregnant and planning to be pregnant. Zerodol should not be used as it interferes with fertility and may cause harm to the growing fetus.
  • Breastfeeding mothers should not use Zerodol unless the benefits outweigh the risks.
  • Inform your doctor of all medical condition you have or have had to prevent adverse reactions that may be fatal.
  • Inform your doctor of all the medication you are using or have been using to avoid severe drug interactions.
  • Using Zerodol for a longer duration can result in severe bleeding.
  • Do not use alcohol and tobacco while you are taking Zerodol as in may cause stomach bleeding.
  • In the case that Zerodol makes you dizzy or drowsy, do not engage in activities that require mental alertness like driving and operation of heavy machinery.
  • Taking very high doses of Zerodol can result in heart attacks or stroke.
  • Zerodol is better used when the symptoms of your condition begin for it to work well rather than letting the condition progress.
  • Zerodol should not be used in children under the age of 18 years as its safety and effectiveness are yet to be established.
  • Zerodol should be stored at room temperature away from heat and moisture.
  • Do not take Zerodol that is expired. Always check the package for expiry date. Expired medications have reduced effectiveness and may be toxic.
  • Zerodol is advised to be taken with food or after a meal to avoid stomach upset and should be taken with a lot of water.

Different Brands and Manufacturing Companies of the Drug

Zerodol is manufactured by IPCA Laboratories Pvt Ltd and Navana Pharmaceuticals Ltd. Zerodol comes in the form of a capsule, tablets, and injection. The tablets can be of different strengths of 100 mg and 200 mg and also in combination with other ingredients. Other brands of Zerodol from IPCA Laboratories Ltd include:

  • Zerodol P tablet contains 500 mg Paracetamol and 100 mg Aceclofenac
  • Zerodol S tablet contains 100 mg Aceclofenac and 15 mg Serratiopeptidase
  • Zerodol SP tablet contains 100 mg Aceclofenac, 325 mg Paracetamol/Acetaminophen and 15 mg Serratiopeptidase.
  • Zerodol TH OD 200 mg/16 mg capsule SR contains 200 mg Aceclofenac and 16 mg Thiocolchicoside.
  • Zerodol PT tablet contains 100 mg Aceclofenac, 325 mg Acetaminophen/Paracetamol and 37.5 mg Tramadol
  • Zerodol PG 200/150 tablet SR contains 200 mg Aceclofenac and 150 mg Pregabalin
  • Zerodol TH OD 200 mg/8 mg capsule SR contains 200 mg Aceclofenac and 8 mg Thiocolchicoside
  • Zerodol Spas tablet contains 80 mg Drotaverine and 100 mg Aceclofenac
  • Zerodol TH 4 tablet contains 100 mg Aceclofenac and 4 mg Thiocolchicoside
  • Zerodol CR tablet contains 200 mg Aceclofenac
  • Zerodol 150 mg injection contains 150 mg Aceclofenac

Substitute drugs

Substitute drugs with the same composition and strength as Zerodol include:

  • Aceclo 100 mg tablet – Aristo Pharmaceuticals Pvt Ltd
  • Aceroc 100 mg tablet- Wockhardt Ltd
  • Aroff 100 mg tablet – Unichem Laboratories Ltd
  • Dolowin 100 mg tablet – Micro Labs Ltd
  • Mahanac 100 mg tablet – Zuventus Healthcare Ltd
  • Rofalco 100 mg tablet – Sun Pharma Laboratories Ltd
  • Movexx 100 mg tablet – Cipla Ltd
  • Xadoo 100 mg tablet – Zydus Cadila
  • Mahanac 100 mg tablet – Zuventus Healthcare Ltd
  • Movace 100 mg tablet –Alkem Laboratories Ltd
  • Hifenac tablet – Intas Pharmaceuticals Ltd
  • Topnac 100 mg tablet – Systopic Laboratories Pvt Ltd
  • Movon 100 mg tablet – IPCA laboratories Ltd
  • Akilos 100 mg tablet – Unison Pharmaceuticals Pvt Ltd

 

 

 

Related Posts

Trending Topics

hidden benefits walking
9 benefits of walking we bet you didn’t know! Did you know walking can be the miracle pill for eternal youth? Everyone knows walking…
eating disorder anorexia
Eating Disorders: Lifestyle choice or a psychological condition? Is eating disorder just a harmless bad habit? Or does it represent grim psychological disorders?…
understanding addiction
Addiction explained: An obsession that could cost you your life Is addiction a behavioral disorder? Or is it a chronic disease? How does addiction cause…
50 common health conditions
What are the top 50 deadly and widespread diseases? A complete list of the top 50 most common and deadly diseases that plague humanity.…
low carb foods spinach
Low carb vegetables: A complete list of what to pick from during a keto diet Is your plate of veggies making you fat? Are all vegetables created equal? Research reveals…
social media adddiction
Your health in the age of Social Media: Why is digital detox a necessity? Did you know that more than 400 million people are dangerously addicted to social media?…
fitness routine fun
10 fantastic ways to make your fitness routine more fun! Are you too bored to exercise? Do you avoid gym cause it's too monotonous? Looking…
boost immunity tips
Step up your defence: 15 proven tips on how to boost your immunity Want to naturally build up a stronger immunity? Tired of frequent colds and runny nose?You…
sleep deprivation
Don’t let your sleep deficit grow into memory loss or heart attack Why is sleep important for us? How could sleep deprivation harm you? We bet you…
canola oil cooking
Canola oil: How safe is it to consume this popular cooking oil? Extracted from rapeseeds, Canola oil derives its name from Canadian Oil. Did you know that…
Jicama: A fiber-rich tuber for your weight loss goals Pronouced as HEE-kah-ma, Jicama is the "new kid on the block" that has taken the…
stress depressed anxiety
Are you depressed or just stressed? Know when to see a doctor Why are some people more anxious than others? Is being depressed the same as feeling…
yoga health benefits
How to practice yoga for astounding health benefits Can a 5000-year-old system be the ultimate body healer? Did you know yoga can make…
acne removal tips
Anatomy of acne: 7 instant steps to kiss those zits goodbye Blackheads, whiteheads, or pimples-call them what you may. Acne is never good news.Did you know…
waking up tired
10 reasons why you might be waking up tired Do you feel you are not getting enough sleep? Sleep-deprived and frustrated? Read on discover…
dandelion health benefits
Dandelion: Little parachutes of health and wellness for your whole body Dandelions are not just bright looking blossoms that cheer your mind. These are powerpacked with…
IIFYM diet shopping
If it fits your macros (IIFYM) : A contemporary macro diet regime A diet that lets you eat everything- sounds unbelievable, right? Well, with IIFYM now you…
Kratom drug banned
Kratom: Why is this distant cousin of coffee banned in numerous countries? The name Kratom has often stirred controversies ; this psychoactive drug is both the cure…
maltodextrin sugar
Maltodextrin: What are the hidden health benefits of this food additive? Maltodextrin is one of the few food additives that has been relatively deemed safe. Many…
stress adverse effects
Fight, flight, or freeze: 8 ways stress can ruin your body Did you know that stress is in-built in our systems? It helped our ancestors respond…
oral hygiene tips
6 shocking consequences of bad oral hygiene (and how to avoid them) Did you know bad breath is not just turning off, but also harms your body…
back pain relief
Don’t choose pain: 10 truths about your back ache (and how to get relief) Back pain is one of the most common ailments in the world. Almost 80% of…
Isagenix diet
Isagenix Diet: Do you really need liquid meal replacements to lose weight? Isagenix Diet - What are liquid meal replacements and why is the world going ga-ga…
Ketosis bad breath
Ketosis: A potentially dangerous side effect of the popular keto diet? Ketosis occurs when you have too low carb intake. Though it means rapid fat loss,…
Moringa drink
Moringa: This could be the most nutrient-dense food known to us! Moringa is a lush green tree brimming with over 90 essential nutrients required for a…
eating myths debunked
8 ‘healthy eating’ myths you believed until now Is a zero-carb diet really healthy for you? Are organic products worth their cost? Did…
Panera bread steak arugula
Panera Bread: The truth behind this “healthy” restaurant chain What to order and what to avoid when dining at Panera Bread ? Know more…
Jack in the box fast food
Jack In the Box : The perils of surging fast food culture in the USA Jack in the Box - How a culture of fast-food can clog your arteries, weaken…
Fluoride: An indispensible mineral or a potential toxin ? Fluoride, the main ingredient of toothpaste, has shown a great potential as a cleanser. However,…
improve digestion weight loss
Power up your gut: 8 proven steps on how to improve your digestion Did you know you have a colony of bacteria in your gut that help you…
ashwagandha brain
Ashwagandha: The best-kept secret of Ayurveda now revealed! Ashwagandha literally means "smell of horse". Don't get bogged down by that one tiny detail…
chia seeds weight loss
Chia seeds: How to consume this staple Aztec food to get a leaner body Chia seeds: What is the actual reason for its sudden popularity? Why are celebrities swearing…
Garlic health benefits cloves
Garlic: Nature’s white pill as an effective home remedy What are the secrets hidden in these tiny white pills? Find out the immense health…
passion fruit juice
Passion fruit: How one exotic fruit can help you fight infections and cancer! Passion fruit: Why does this exotic fruit have such an enticing name? And how can…
hidden causes obesity
8 hidden causes of obesity you probably didn’t know! Did you know that around 2 billion people worldwide are either overweight or obese? Are…
liver detox facts
7 liver detox facts and why ignoring these could kill you! Are you taking care of this organ that handles over 500 different vital functions in…
Whole30 diet fad
Whole30 Diet – Why eliminating certain foods just doesn’t cut it Whole30 Diet: Is this the ‘whole’-y grail of a disease-free body? Read more to find…
lose pregnancy weight
5 most effective ways you can lose those pregnancy pounds! Are you looking for ways to get back into shape? Scared of crash diets? Don't…
MANUKA HONEY child
Manuka Honey Manuka honey is a specific type of honey produced by honey bees that collect nectar…
castor oil hair
Castor oil : A vitamin-rich oil for shiny locks and healthy bowels Castor oil bestows unlimited benefits, whether you use it for your hair or skin. But…
iron food shellfish
Iron-Rich Foods: Eat these foods to keep fatigue and anemia away! How to ensure a muscles as strong as iron? Eat iron rich foods ! Iron…
kale
Kale: With more iron than beef, this superfood is the ultimate way to lose weight Checkmate meat-eaters; with kale, vegans now have the ultimate iron-rich superfood as their ally that…
low fodmap plan
Troubled with IBS? Here’s a complete roadmap to the low FODMAP diet Leaky & inflammatory gut troubling you? No medicine bringing you relief from the pain? Why…
superfoods quinoa probiotics
10 fantastic Superfoods you need to include in your diet from today! What exactly are superfoods and how do they battle diseases? From losing weight to looking…
alcohol toxic
7 startling facts that will make you quit alcohol today Does drinking really make you friendly and happy? How many calories does a can of…
Healthy pregnancy tips
How to have a healthy pregnancy: Essential tips to remember What to expect when growing a life within you? How important are prenatal vitamins anyway?…
top 5 deadliest cancers
A sneak peek into the top 5 deadliest cancers and the true nature of their origins Did you know that cancer is the 2nd leading cause of deaths globally? Among the…
paleo keto diet
Paleo vs. Keto: Which diet plan is best suited for your body goals? Is eating like a caveman the right way to go? Can you really eat fats…
autoimmune diseases facts
Autoimmune Diseases: Find out if your body is attacking you right now Did you know your body can harm itself? What are autoimmune diseases and why does…
antibiotic resistance
Antibiotic Resistance: How common diseases become deadly Can a cold kill you? How important is to get a flu shot? Why do…
vital organ diseases
Common diseases that could cripple your vital organs Brain, heart, kidney, lungs, and liver - these vital organs are indeed vital for your…
Creatine: Is this the right peak athletic-performance supplement for you? Creatine is the amino acid that boosts our energy. Did you know creatine supplements can…
nutritional yeast bread
Nutritional Yeast : How can a fungi culture be good for your body? Nutritional yeast: How a simple culture of fungi can transform your skin, digestion, immunity ,…
Nitric oxide: Why is this heart-healthy supplement every sportsman’s first choice? Once considered a vastly toxic substance, nitric oxide is now deemed to be a great…
gallbladder diet tomato
Gallbladder surgery :Tips on post-operative care and diet What to eat post a gallbladder surgery? What are the key things to avoid if…
nature health benefits
Green Healing: The amazing health benefits of being in nature You have no idea what sitting in a closed room does to your body and…
about mediterranean diet
Why you should be adopting a Mediterranean style of diet today Ever wondered why the Mediterranean diet is so healthy? One simple solution to lowering risk…
common mental disorders
Common mental health disorders :The silent stigma surrounding millions More than 300 million sufferers and yet a silent and agonizing stigma; why are people…
lose weight fast
12 easy and instant steps to successful weight loss Do you want to lose weight without losing your mind? Does weight loss always mean…
low carb diet meal
Low carb diet : Go high on fats and low on carbs for a leaner body! Did you know that sugar is the new fat? Going low on carbs and high…
High Fiber Diet – Fire up your fiber intake for these health benefits! Regular bowels, healthy detox, higher immunity, and guaranteed weight loss - a high fiber diet…
boost brain health
The ultimate tips on how to boost your brain health Would you like to be smarter? Want a sharp memory but bored of doing sudoku?…
health benefits coffee
Dark, hot, & steamy: The remarkable health benefits of drinking coffee Coffee does more than just wake you up. One of the most widely consumed beverages…
matcha tea leaves
Matcha: The unthinkable health benefits of this unique green tea Did you know that a cup of matcha can boost your immunity against toxic diseases?…
Military diet
Military Diet : Why following a highly restrictive diet is a bad idea Is seiging your calorie intake the right way to attack fats? Read more about Military…
BCAAs powder
BCAA: Now get more out of your workouts with this miracle protein BCAAs are counted as one of the best supplements for increasing your physical endurance. Find…
Milk Thistle skin
Milk Thistle: Find possible cures for fatal diseases in these purple blooms Milk thistle is well-known for treating liver conditions. However, did you know that it comes…
CBD oil safe
Cannabidiol benefits: Evaluating the “highs” of CBD Oil The word cannabis paints a picture of addicts. But did you know that CBD oil,…
green poop causes
Green poop : What are the reasons and how can you correct it Ever sneak a peek down the toilet only to shockingly find green poop? Why does…
kefir bottle
Kefir: Top reasons why this probiotic drink should be consumed by you Yet another remarkable fermented food, kefir is a much healthier version of yogurt. These chewy…
cancer facts
8 hard-hitting truths no one tells you about cancer Did you know that 1.5 million new cases of cancer are reported every year? Can…
turmeric skin
We bet you didn’t know that turmeric could be this beneficial! Did you know that turmeric, a humble ingredient found in most Indian kitchens could cure…
dance health benefits
5 unbelievable effects of dance on your overall health! You enjoy dancing, but did you know what else it does to your body? Dancing…
Serotonin happiness
Serotonin : What you didn’t know about this “feel-good” chemical Serotonin : Did you know that this "feel-good" hormone could well impact your sleep cycle,…

Related Posts