Multiple Myeloma

MULTIPLE MYELOMA backpain

Last Updated December 20th, 2021

Overview

Cancer is any condition involving the uncontrolled growth of cells to such an extent that this disturbs the normal physiological processes of the body. Blood cancer can be of several types since blood is composed of many different kinds of cells and these can be affected in various ways. Leukemia and lymphoma are well known cancers of the blood. Another less well known but related type of blood cancer is multiple myeloma. This malignancy arises in the blood plasma cells which are usually present in the bone marrow. This disease is hereditary in a small number of cases.

 

What Is Multiple Myeloma?

MULTIPLE MYELOMA bone marrowA multiple myeloma is a form of blood cancer that arises when the plasma cells multiply uncontrollably and form tumors. The function of plasma cells is to produce antibodies that help the body fight pathogens. When plasma cells turn malignant, they fail to perform this function and even prevent the production of others kinds of healthy blood cells. Unlike normal plasma cells, they do not die out when they have worn out or become damaged.

As a result, they accumulate progressively until the bone marrow becomes saturated with defective and malignant plasma cells known as myeloma cells. These malignant cells may be scattered throughout the bone marrow or they may clump together into a plasmacytoma. Multiple myeloma is the condition wherein several such growths arise in the body.

 

What Are Its Causes?

The marrow is the spongy core of the bones and this is where blood cells develop. The three main types of blood corpuscles are white blood cells, red blood cells, and platelets. Each has a distinct set of functions. White blood cells fight infection and foreign bodies. When there is an infection in the body, a certain type of white blood cell known as a B-lymphocyte transforms into a plasma cell. It is these cells that are affected when a person has multiple myeloma.

The function of a plasma cell is to produce antibodies that enable the body to disable pathogens. Plasma cells are capable of producing a variety of antibodies. Certain genetic changes or mutations within plasma cells can trigger the transformations that turn them into malignant cells. Unlike normal cells, these malignant ones do not die when they wear out or get damaged. As a result of this, there is an abnormally high accumulation of defective plasma cells (myeloma cells) and not enough healthy ones. These malignant myeloma cells clump together to form masses known as a plasmacytoma.

The reasons behind the initial genetic mutation are not well understood. In fact, abnormalities in bone marrow cells may also have a bearing on plasma cells turning malignant.

 

Risk Factors

MULTIPLE MYELOMA appetite lossResearch has uncovered certain factors associated with an elevated risk of developing multiple myeloma:

  • Having a close relative with this disease roughly quadruples one’s own chances of developing it.
  • Being overweight or obese.
  • Exposure to radiation.
  • Having other diseases associated with plasma cell abnormalities. This includes solitary plasmacytoma and monoclonal gammopathy of undetermined significance (MGUS).
  • The risk increases with advancing age. The incidence of this disease is particularly high in those over 65 years of age.
  • Certain racial groups are more susceptible than others. For instance, African Americans are more likely to develop multiple myeloma than white Americans.
  • Men are more likely to be affected than women.

 

What Are The Effects of Multiple Myeloma?

A myeloma cell is programmed to multiply indefinitely. Thus, it produces millions of copies or clones of itself, all of which contain the same genetic defect. Although these are different from plasma cells, they do make antibodies. Where healthy plasma cells will produce different types of antibodies in specified quantities in response to infection, myeloma cells, on the other hand, are like machines that cannot be switched off. Even when there is no infection in the body, myeloma cells continue to manufacture antibodies.

Since myeloma cells are all clones of each other, they produce vast quantities of the same kind of antibody, earning these antibodies the name ‘monoclonal proteins’ or ‘M-proteins’ for short. Just like other antibodies, M-proteins are a combination of molecular chains. They include two pairs of one light protein chain and a heavy protein chain each. Typically, myeloma cells tend to produce more light than heavy chains, leading to an excessive buildup of free light chains.

The following are typical features of this disease:

  • Higher susceptibility to infection: A healthy body will have small quantities of normal antibodies produced by healthy plasma cells. In a person who has multiple myeloma, M-proteins are often present in excessive quantities. This condition is known as monoclonal gammopathy. As a result, the person’s immune system becomes weak, increasing susceptibility to infection.
  • Bone problems: Myeloma cells produce chemicals that accelerate the process of breakdown of bone, weakening bone tissue. This leads to the elevation of the quantity of calcium in the bloodstream (hypercalcemia).
  • Anemia and thrombocytopenia: The overgrowth of myeloma cells inhibits the production of other kinds of normal blood corpuscles. When numbers of red blood cells drop steeply this leads to anemia and the organs and tissues become starved of oxygen. Lack of platelets is known as thrombocytopenia and this results in a lower ability of the blood to clot in the event of injury.
  • Light chain amyloidosis: Excess light chains (amyloids) form deposits in the tissues and organs disturbing their normal functioning. A load of abnormal deposits builds up faster than it can be cleared out. Hence, this is a progressive condition in the absence of effective treatment. Organs such as the kidney and heart may eventually fail as a result of an excessive light chain amyloid load.

 

Specific Symptoms

  • MULTIPLE MYELOMA backpainFatigue.
  • Shortness of breath.
  • Dizziness.
  • Drowsiness.
  • Bone pain that may arise in any area such as the hips, ribs or back.
  • Frequent and recurrent infection and fever.
  • Reduced ability of the blood to clot. There may be excessive bleeding from minor cuts or injuries.
  • Darkened purple lumps below the skin.
  • Swelling of the legs.
  • Loss of appetite.
  • Abdominal pain.
  • Kidney problems.
  • Increased susceptibility to fractures.
  • Thickening of blood because of excessive M-proteins.
  • Dehydration.
  • Excessive thirst.
  • Frequent urination.
  • Constipation.
  • Neurological symptoms such as numbness and mental confusion on account of nerve damage.
  • Irregular heart rhythm.

 

What Are The Different Types of Multiple Myeloma?

There are several possible variants of multiple myeloma. These are:

  • Indolent Multiple Myeloma: In this case, the condition is largely asymptomatic although there is a high likelihood of progression into symptomatic disease eventually.
  • Active Multiple Myeloma: This form of the disease is symptomatic. Features such as anemia, bone lesions, plasmacytomas and kidney problems may all be present. M-proteins will be present in the blood and urine.
  • Solitary Plasmacytoma of the bone: This presents with a single tumor composed of myeloma cells and located within the bone. Apart from pain at the affected site, there may be none of the other typical features of multiple myeloma. Eventually, the patient is likely to develop more such growths.
  • Extramedullary Plasmacytoma: Clumps of myeloma cells arise in other parts of the body apart from the bone marrow. Usually, they appear in the soft tissues, in the respiratory tract, gastrointestinal tract, brain or breasts. The patient may have purplish lumps just below the skin if the growths are present in those areas.
  • Light Chain Myeloma or Bence Jones Myeloma: In this form of the disease, the myeloma cells produce only light protein chains. They do not produce heavy chains. This often leads to kidney damage. It accounts for about 15-20% of cases of multiple myeloma.
  • oligosecretory or Non-Secretory Myeloma: Typically, the myeloma cells produce vast quantities of M-proteins. However, in this case, it is not so. There may be only small or negligible output of M-proteins. However, the bone will exhibit lytic lesions.
  • ImmunoglobulinD Myeloma: Patients with this type tend to be somewhat younger than in other cases. This form of cancer is rather rare.
  • Immunoglobulin E Myeloma: This is the least common type. It follows an aggressive course and rapidly progresses beyond the bone marrow.

 

What Complications Can It Give Rise To?

There can be a range of severe and critical outcomes in instances of multiple myeloma:

  • The body becomes unable to mount a robust immune response in case of infection, leaving the patient susceptible to all kinds of infectious disease. In fact, complications are likely to arise as a result of these infections that are unrelated to actual cancer itself.
  • Abnormal thickening of the blood means that blood supply to vital organs such as the brain may reduce and this can lead to severe complications. Patients may need to remain on a course of blood thinners in order to keep such problems at bay.
  • Fractures as a result of the weakening of bone tissue.
  • Organ failure as a result of amyloid builds up. Usually, the kidneys tend to suffer.
  • Extreme hypercalcemia can render the patient comatose.
  • Spinal cord compression can develop when the bones of the vertebrae sustain damage or fractures. This leads to numbness, pain, and weakness of muscles and warrants urgent medical attention.

 

What Is The Procedure For Diagnosing Multiple Myeloma?

Generally, symptoms do not manifest until the disease has reached an advanced stage. The following tests provide indications that help in making a diagnosis of multiple myeloma:

  • Blood tests: Complete blood count tests help diagnose anemia and thrombocytopenia. Free light chains may be present in the blood. A viscosity of the blood may also be abnormal. Blood chemistry tests measure the levels of substances such as blood urea nitrogen, creatinine, and albumin besides electrolytes like calcium. This helps assess kidney function.
  • Urine tests to look for free light protein chains.
  • Electrophoresis tests measure quantities of antibodies and detect the presence of M-proteins. This involves testing both blood and urine samples.
  • Imaging tests to check for tumors in other parts of the body.
  • Tissue biopsy. This involves examining samples of bone tissue under a microscope to look for signs of damage.

 

Treatment & Prevention

Conditions such as multiple myeloma require treatments done in two phases. One is a local treatment which involves treating the cancerous tumor without affecting the rest of the body. The second is a systemic treatment which includes therapies that are aimed at cancer cells that have traveled to other parts of the body.

  • Local treatment involves surgery and radiation therapy. These are employed if the myeloma is in its early stages.
  • Systemic treatment is done with the help of chemotherapy, stem cell transplant, biphosphonate, or plasmapheresis. The method employed here depends on which stage cancer has progressed to.

It is important to discuss all possible treatment methods to treat myeloma along with the side-effects of each. Also, make sure that you get a second opinion as well for diagnosis and treatment of myeloma. There are no specific ways that will guarantee a complete prevention from multiple myeloma. However, controlling the associated risk factors can reduce your chances of developing this condition.

These precautionary methods include:

  • Consuming a low-fat, balanced diet with healthy amounts of antioxidants.
  • Refraining from smoking (both active and passive).
  • Avoiding exposure to hazardous chemicals such as asbestos, pesticides etc.
  • Getting complete vaccination for viral diseases such as hepatitis.
  • Practicing safe sex that hinders the spread of HIV.
  • Protecting yourself from harmful radiations that can cause myeloma.

Facts

  • Multiple myeloma can occur in those regions where the bone marrow is active. In adults, these regions include the skull, spine, pelvis, ribs, and the shoulders.
  • The exact cause for multiple myeloma still eludes the medical community. The associated risk factors include genetic abnormalities and environmental toxin exposure.

Facts

  • The median survival associated with multiple myeloma is about 3 years, though there are patients who have lived for almost 10 years.
  • 96% of the diagnosed cases of myeloma are done in patients above 45 years and older. Only 1% of cases are detected people less than 32 years of age.

Facts

  • Toxic substances such as asbestos, benzene, and pesticides increase the risk factor. Thus people involved in leather, petroleum, agriculture, cosmetology industries are at high risk.

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Dos and Don'ts

Dos
  • Discuss with your doctor and cancer team regarding the side-effects of the treatment prescribed (chemo or radiation therapy).
  • Ask for help from people around you for day-today tasks as myeloma makes you more vulnerable to pains, fractures, and infections.
  • Go for each and every follow-up appointment and discuss the progress of treatment and side-effects experienced by you clearly with the doctor.
  • Get prompt treatment for any systemic condition that might occur as a part of the therapy such as hypercalcemia.
Don'ts
  • Completely rely on alternative treatment methods such as herbal supplements or special diets. None of these have received any form of approval from major government bodies.
  • Practice unhealthy dietary and lifestyle habits. Indulge in healthy physical exercises and consume a nutritious diet.
  • Expose yourself to harmful environmental toxins and infections. Practice proper hygiene and sanitation.

 

 

 

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Oil of Oregano: The one-stop essential oil you’ve been looking for Are you plagued by a weak immune system? High body inflammation accompanied by pain and infections? Why not…
Gingko Biloba: Therapeutic lessons from the world’s oldest tree The Ginkgo Biloba, well known as the maidenhair,is the oldest living tree and the oldest living fossil. It…
Tart Cherry: The healthiest excuse for taking that second serving of pie Tart cherry has been traditionally used in delectable desserts such as pies. Recent studies have revealed that its…
sodium chloride
Halotherapy: How inhaling salt can work wonders for your body Halotherapy is quickly gaining popularity amongst those with respiratory diseases. It has shown promise in its treatment.
Surgery or home-remedy; what is the right way to treat a burn The treatment of a burn injury depends on its severity. You can save a life by offering the…
Poop chart: Top things you didn’t you your poop could reveal about you Bristol poop chart was designed during the 1990s in order to help doctors identify various types of poops…
Ear pain model
Easy and safe tips for ear wax removal you can do at home Cerumen impaction generally occurs when an external object like cotton swabs are used to remove the ear wax.…
TSH test
TSH Test – Thyroid Stimulating Hormone TSH test measures the level of thyroid secreting hormone in the blood. The level of this hormone is…
Barium-enema
Barium Enema Barium enema is also known as colon x-ray. Here, the patient is asked to consume small amount of…
EEG
Electroencephalogram – EEG EEG or electroencephalogram is a diagnostic tool used to access the functioning of neurons and brain activity to…
blood elements analysis
Blood Element Analysis Test A blood element analysis is a blood test performed to measure the level of toxic elements such as…
beta 2 glycoprotein 1 IgG
Beta 2 Glycoprotein 1 IgG Beta 2 glycoprotein 1 antibody test involves detecting and measuring the presence of the IgG class of beta…
cystatin C
Cystatin C Test Cystatin C is a specific single-chain protein that is found in body fluids and is a biomarker for…
copper serum test
Copper Serum Test Copper serum test checks for abnormal levels of copper in the body. Both high and low levels of…
eating disorder anorexia
Eating Disorders: Lifestyle choice or a psychological condition? Is eating disorder just a harmless bad habit? Or does it represent grim psychological disorders? Do you want…
carrageenan seaweed
Carrageenan: How a simple seaweed extract could better your gut health & immunity Eat more ice cream to prevent cold and flu? –With carrageenan you get one simple seaweed extract that…
occupational hazards types
Occupational Hazards: How to vouch for your health at your workplace Occupational hazards affect millions worldwide. Chemical spills, faulty wires, deadly pathogen, and work-stress can happen anytime. Follow these…
Jack in the box fast food
Jack In the Box : The perils of surging fast food culture in the USA Jack in the Box - How a culture of fast-food can clog your arteries, weaken your heart, fatten…
Garlic health benefits cloves
Garlic: Nature’s white pill as an effective home remedy What are the secrets hidden in these tiny white pills? Find out the immense health benefits of using…
Cordyceps: How the Caterpillar fungus works as a proven cancer-shield Strange as it may sound, but cordyceps or "caterpillar fungus", a fungus variety native to the Himalayas may…
GM Diet: The fastest way to lose weight or yet another hoax diet? General Motors started this trend of extreme dieting for 7 straight days to ensure its employees were able…
waterchestnut
Water Chestnuts: The tastiest ways to include this healthy tuber in your diet Water chestnut is not a nut after all. It is a tuber (much like the potatoes) growing close…
Oxalates: How healthy greens can sometimes be bad news for your kidneys Oxalates are compounds present in a majority of healthy foods. However, at times an overconsumption of these could…
Sciatica pain relief: Get rid of the pain with these easy daily tips Researchers have claimed that not only heat but icing the area too helps relieve sciatica pain. Find out…
How to scrub away stress and fatigue with an Epsom salt bath? Epsom salt is a popular home remedy for many skin ailments. Though there is a lack of scientific…
6 arguments in favour of glucosamine and where can you find it Studies have shown that glucosamine works by preventing the breakdown of cartilage of the joints. This is usually…
Chest X-Ray A chest x-ray is a diagnostic test that uses x-rays to visualize the structures inside your chest. It…
LFT-test
Liver Function Test – LFT LFT or Liver Function Test is a blood test used to determine the levels of hepatic enzymes which…
thyroid_scan
Thyroid Scan Thyroid scan is a diagnostic procedure that aims to view the thyroid gland and detect any growths or…
Rubella IgM test
Rubella IgM Test The Rubella IgM test is a blood test that is performed to diagnose the presence of the rubella…
HSV-IgM test
Herpes Simplex Virus (HSV)-IgM Test The HSV-IgM class antibody is produced by the body a few days after an initial HSV infection and…
apolipoprotein a1 test
Apolipoprotein -A1 (APO-A1) Test Apolipoprotein A-I (Apo-A1) constitutes 70% of protein content in high-density lipoprotein (HDL) and helps in lipid metabolism.
nutritional yeast bread
Nutritional Yeast : How can a fungi culture be good for your body? Nutritional yeast: How a simple culture of fungi can transform your skin, digestion, immunity , and much more.…
calories healthy
Calories: How to keep a check on these for faster weight loss Did you know you can burn calories while sleeping? Calorie-burning is what causes weight loss. How much should…
hYdroxycut pills
Hydroxycut: How safe are these so-called weight loss supplements? Hydroxycut is a blend of several different ingredients formulated to promote weight loss; powered by a key weight…
Anhedonia: Does the chronic inability to feel joy affect you too? How often do you feel dragged down by an invisible force? Do you feel an inexplicable emotional numbness…
Plexus Slim: Is this pink slimming drink the ultimate one-stop fat burner? How effective is Plexus Slim in helping people lose weight? What are its ingredients? Can it be safely…
Ear infections check up
Troubled with ear infections? Find easy and instant home remedies here Ear infections are common in both children and adults and may lead to hearing loss if left untreated.…
Appendix pain: Recent findings on this not-so vestigial organ The exact function of the appendix is still not clear. Some consider it as an organ that once…
Top reasons why you need to pay attention to your vitamin B6 intake Vitamin B6- An essential water-soluble vitamin. Its deficiency leads to physical changes such as sores & glossy tongue…
liver cleanse detox
14 go-to foods that are best for a complete natural liver detox Liver cleanse can be achieved by just choosing or avoiding certain types of food. Liver itself is a detoxifying…
PROSTATE-SPECIFIC-ANTIGEN
Prostate-Specific Antigen (PSA) Test Prostate specific antigen test is a blood test used to determine the presence of prostate cancer or any…
anoscopy
Anoscopy Anoscopy is an invasive diagnostic procedure where a small device known as anoscope will be inserted in the…
lp-pla2
LP-PLA2 Test The LP-PLA2 test is a test which is carried out to assess the levels of Lipoprotein-Associated Phospholipase A2…