Acanthosis nigricans

Acanthosis nigricans neck

Last Updated December 20th, 2021

Overview of acanthosis nigricans

The scenario of skin diseases and infections is very grave in India. According to the statistics of Biospectrum India, the incidence rate of different types of skin diseases was nearly 10% in the year 2013. They also predicted that around 188 million people (12% of the total population) are likely to suffer from serious skin diseases by the year 2015. A particular skin disease known as acanthosis nigricans has worried the dermatologists worldwide in the recent years. It has been traced to environmental factors as well as certain existing diseases. The current research works are being directed towards devising advanced treatment techniques for acanthosis nigricans.

What is acanthosis nigricans?

Acanthosis nigricans neckAcanthosis nigricans is a type of skin disease in which blackish or brownish discoloration of the skin occurs along with a velvety appearance in different portions of the body. These patches are commonly seen at the back of the neck, in the groin and armpit. It can also appear in some other parts of the body that have skin folds, such as chin, lower lips, forehead, and navel. Occasionally it is seen on the knuckles as well. It results from the thickening of the skin surface. In due course of time, the skin texture may change completely.

What causes acanthosis nigricans?

Acanthosis nigricans is common in people who are obese or overweight, the primary reason being the presence of a large number of folds. People having diabetes and glucose intolerance are also found to have the disease. At present, nearly 8.7% in the urban areas and 7.9% in the rural areas have varying levels of glucose intolerance. These people are at greater risks of having acanthosis nigricans. Endocrinal disorders, medicines, and malignancy are also some of the major risk factors for the disease. People having certain serious diseases like Hypothyroidism, Polycystic Ovary Disease, Cushing’s syndrome and acromegaly are also equally likely to suffer from acanthosis nigricans.

What are the symptoms of acanthosis nigricans?

Acanthosis nigricans should be distinguished from other skin diseases that result in patches and eruptions. The following signs should be noted-

  • Dark brown or blackish patches in the skin folds
  • Velvety appearance of the affected region
  • Thickened skin texture
  • A difference in color between the affected region and the adjoining skin
  • Spreading of the patches to the neighboring regions
  • Skin irritation (rare)
  • The appearance of skin tags at a later stage
  • The appearance of additional skin folds in the advanced stages

Get improved and pigmentation-free skin with these dermatologist-recommended solutions.

What are the different types of acanthosis nigricans?

Acanthosis nigricans endocrineBased on the nature of the disease, acanthosis nigricans can be divided into two classes-

  • Benign: This type of acanthosis nigricans does not cause additional systemic complications. It arises from endocrinal disorders and overweight conditions. It may have some hereditary linkage in some cases.
  • Malignant: This type of acanthosis nigricans may give rise to malignancy in future. They are often associated with tumour-necrosis factor and abnormalities in insulin processing.

Based on the aetiology, acanthosis nigricans is of the following types-

Type I: It is also known as familial acanthosis nigricans. It is basically an autosomal dominant trait that is usually present at birth. It may also develop at some later point of time, say in teenage or adulthood.

Type II: This type stems from endocrinal disorders. The onset symptoms are not so identifiable, though the process already starts. Type II acanthosis may develop under the following conditions-

  • Metabolic syndrome, insulin resistance, diabetes mellitus
  • Excess androgen in Cushing’s disease, polycystic ovary, acromegaly
  • Addison’s disease
  • Hypothyroidism
  • Rare diseases like Alstrom syndrome, Prader-Willi syndrome, Ovarian hyperthecosis, pituitary basophilism, pineal hyperplasia syndrome

Type III: This is also known as Pseudo Acanthosis Nigricans. It is more common in obese people. In such cases, this disease is a strong indicator of insulin resistance. The extent of skin pigmentation in this case has a positive correlation with the degree of insulin resistance. Both Type A and Type B insulin resistance syndromes are responsible for skin pigmentation in this case. It is more likely to occur in people with dark complexion and is difficult to identify. For this reason, it is also known as Pseudo Acanthosis Nigricans.

Type IV: This type occurs as a result of drug abuse or overuse. Some of the common drugs responsible for this condition are- oral contraceptive pills, glucocorticoid and a few others. People undergoing growth hormone therapy may also develop Type IV acanthosis.

Type V: This type of acanthosis nigricans is associated with malignancy. It is very often known as a paraneoplastic syndrome. This type is usually associated with-

  • Genitourinary Cancers
  • Gastrointestinal Adenocarcinomas
  • Lymphoma

Acral acanthotic anomaly: It is yet one more variant of acanthosis nigricans, wherein dark patches appear on the knees, knuckles, elbows and the dorsal surface of the feet.

Diagnosis

For the diagnosis of acanthosis nigricans, the doctors primarily go through the patient’s family history. Next, they conduct a physical examination. It may include but need not be limited to the following tests-

  • Skin biopsy (to rule out cancer)
  • Blood test (Complete Blood Count)
  • Endoscopy (to eliminate gastrointestinal causes)
  • X-rays (to rule out diabetes)
  • Differential diagnosis (to distinguish the disease from casal collar seen in Pellagra)

The biopsy results may yield the following findings-

  • Epidermal folding
  • Hyperkeratosis
  • Melanocyte proliferation
  • Leukocyte infiltration

What are the effective treatment and preventive techniques for acanthosis nigricans?

The treatments for acanthosis are targeted towards eliminating the dermal symptoms as well as the clinical conditions causing those symptoms. The doctors may prescribe the following medicines to reduce the pigmentation and alteration of skin texture-

  • Salicylic Acid
  • Alpha Hydroxy acids
  • Retin-A
  • 20% Urea

There are many ways to treat acanthosis nigricans; ranging from topical ointments to cosmetic procedures. You can use an anti-bacterial soap in order to prevent it from getting infected or emanating a foul smell (in case it due to the accumulation of sweat). Topical antibiotics and skin-lightening agent can also be used to get rid of the dark patches. If these steps fail, one can refer to chemical peeling and exfoliation, or even laser treatment.

In order to prevent such skin pigmentation, one should keep a check on blood-sugar levels. Complete hormone profiling should also be done. If you are overweight, try to bring down your BMI to healthy levels. Also, find out if the pigmentation is occurring due to any medication.

Facts

  • If you have type 2 diabetes or are overweight, chances of developing this type of skin pigmentation is high.
  • Drugs such as niacin or OCPs (oral contraceptive pills) can also play a role .

Facts

  • One should cut back on sugar and starch intake to witness improvements.
  • Many opt for cosmetic procedures such as chemical peeling or laser therapy in order to get rid of the dark patches.

Facts

  • This condition usually disappears once the underlying medical condition is treated.

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Dos and Don'ts

Dos
  • This condition results from high-insulin content in the blood. So, try to control your insulin-level.
  • Topical ointments that contain alpha-hydroxyacids and salicylic acid are effective in treating this condition.
  • In some cases, it is a side-effect of a medication and usually goes away once the medication stops.
Don'ts
  • Treat it as a contagious skin disease.
  • Avoid going to the doctor for a complete check-up just because it is relatively harmless.

 

 

 

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GGT – Gamma-Glutamyl Transferase Test GGT or gammaglutamyl transferase test is a liver function test that is used to detect the extent of…
Tight phimosis ring
Phimosis Read to know everything about phimosis, types, symptoms, treatment, risks and prognosis for patients with this condition.
Cayenne: The remarkable benefits of these red hot chili peppers These may make you rush for a glass of water, but cayenne pepper is actually a healthy additive…
Love tea, hate tannins? Rooibos tea is just what you need The market is brimming with a multitude of herbal teas. But what makes rooibos tea (or red bush)…
BRAT Diet: What is the right way to follow this diarrhea-relieving diet? BRAT diet, a simple diet consisting of just bananas, rice, applesauce, and toast, can help you combat the…
What is the right way to take a pregnancy test? A pregnancy test is undertaken to determine if you have conceived. A home pregnancy test is the most…
Gatorade: Top things you need to know about this staple energy drink Gatorade is a popular (in fact the most popular) energy drink worldwide. But this power-packed drinks comes with…
Vagus nerve: 7 health benefits of stimulating the “gut-brain” connection As a matter of fact, there are two vagus nerves namely the left and the right but is…
liver cleanse detox
14 go-to foods that are best for a complete natural liver detox Liver cleanse can be achieved by just choosing or avoiding certain types of food. Liver itself is a detoxifying…
Vitamin-D-blood-test
25-Hydroxy Vitamin D test 25-hydroxy Vitamin D test is a blood test used to measure the level of vitamin D in the…
blood elements analysis
Blood Element Analysis Test A blood element analysis is a blood test performed to measure the level of toxic elements such as…
phenytoin test
Phenytoin test Phenytoin is a drug that is administered mainly to epilepsy patients. The phenytoin blood test measures the level…
malarial antigen test
Malaria Antigen Test A malaria antigen test is a rapid diagnostic test (RDT) that can detect malarial antigens (proteins) in your…
Unbelievable health benefits of gooseberries (and a few tasty recipes) Gooseberries are antioxidant-rich tasty fruits that can be easily added in daily diet to improve overall health and…
piles fissure fistula
Allopathy vs homeopathy vs ayurveda treatment for piles, fissures, and fistula Read to know the best form of treatment among allopathy, homeopathy,or ayurveda for piles, fissures, and fistula
hidden causes obesity
8 hidden causes of obesity you probably didn’t know! Did you know that around 2 billion people worldwide are either overweight or obese? Are you too a…
liver detox facts
7 liver detox facts and why ignoring these could kill you! Are you taking care of this organ that handles over 500 different vital functions in your body? Your…
L-theanine attention
L-Theanine: Better sleep, higher focus, and many other benefits Did you know that L-theanine found in green tea can make you sleep better and be focused at…
Dragon Fruit – Blessing from Nature’s Basket Dragon fruit is packed with nutrients but low on calories. It is the dream food that can help…
Valerian Root: The best way to achieve tranquil sleep every night Valerian root is probably one of the oldest and safest way to cure your insomnia. Find out how…
Did you know drinking alkaline water could be the healthier choice for you? Ever wondered how safe is your drinking water in terms of pH? Recent studies have revealed that Alkaline…
Kava: Is it the healthy substitute for alcohol you have been waiting for? Native to the beautiful South Pacific islands, Kava is a famous beverage rooted in the local culture. It…
Goji berry: A traditional Chinese berry that packs the best of antioxidants Goji berry is an ancient berry that is considered to be power-packed with nutrients and antioxidants. Which means…
Sciatica pain relief: Get rid of the pain with these easy daily tips Researchers have claimed that not only heat but icing the area too helps relieve sciatica pain. Find out…
The Cabbage Soup Diet: The healthiest way to instant weight loss Cabbage soup diet rapid weight loss diet for those who want to shed those extra pounds in less…
shakeology woman
Meal replacement or protein drink? Learn all about Shakeology and its claims Shakeology from Beachbody claims to be the most suitable shake that can aid in weight loss, regulate blood…
C-Reactive Protein Test A CRP or c-reactive protein blood test is an important diagnostic tool used to determine the risk of…
free psa test
Free PSA Test The free PSA test is used to detect the level or percentage of free PSA in the body…
Thyroid disorders
Thyroid Profile Thyroid profile is a panel of blood tests performed to check if an individual is suffering from any…
DHEA wrinkles
DHEA: Now get unbelievable age defiance with this wonder hormone! DHEA is known popularly as the age-defying hormone. This supplement is widely used to slow down aging and…