CA 15-3 Test

CA-15.3

What is a CA 15-3 test?

Cancer antigen 15-3 (CA15-3) test is a blood test that is performed in order to monitor the response to therapy for breast cancer and to assess disease recurrence.

What is CA 15-3?


Cancer antigen 15-3 is a protein formed by many cells in the body, particularly the breast cells. It is found in the blood and is used as a tumor marker (also called serum marker or biomarker) in monitoring therapy for breast cancer.
However, breast cancer cells are not the only ones secreting this antigen. A plethora of malignancies produce this protein, namely

– Lung cancer (both small cell and non-small cell)
– Pancreatic cancer
-Endometrial cancer
-Ovarian cancer
-Hepatic cancer
– Colon cancer
-Prostate cancer

Why has my physician asked me to undergo a CA 15-3 test?

A CA 15-3 test is performed in order to assess the response of your breast cancer to therapy. It can also be used to detect any recurrence of this disease. Elevated levels of cancer antigen 15-3 are seen in approximately 60% of preoperative breast cancer cases and 80% of widespread metastatic breast cancer cases.

You will be asked by your physician to go for this test if you have already been diagnosed with invasive breast cancer and are undergoing therapy for the same.

CA 15-3 test is not endorsed as a screening tool to detect breast cancer in women because it is non-specific. Several other malignancies can lead to elevated CA 15-3 levels in the blood. Moreover, levels of CA 15-3 may be elevated in many benign diseases (including benign breast disorders) and even in healthy individuals.

I have a family history of breast cancer. Should I undergo CA 15-3 test?

No. The CA 15-3 test is not a screening tool for detecting breast cancer. Its levels are not elevated in early stages of breast cancer. Moreover, there are many other conditions (both benign and malignant) which can lead to elevated levels of CA 15-3 in your blood.

What are the non-cancerous conditions that can cause elevated levels of CA 15-3?

Elevated levels of CA 15-3 can be seen in many benign conditions. A few of them are listed below-

– Liver disorders (including chronic hepatitis and cirrhosis)
– Sarcoidosis
– PID (Pelvic inflammatory disease)
Endometriosis
– SLE (Systemic lupus erythematosus)
Tuberculosis
Vitamin B12 deficiency
 
Levels of CA 15-3 are also found to be elevated during pregnancy and lactation.

Do I need to fast before a CA 15-3 test?

There is no need to fast before you undergo a CA 15-3 test. The presence or absence of food in your stomach does not alter the levels of this antigen in your blood and thus does not hamper with the test results.

Can I undergo a CA 15-3 test if I am pregnant?

Yes, you can safely undergo a CA 15-3 test if you are pregnant or breastfeeding your child. However, you need to inform your physician if you fit into the above-mentioned categories as the blood levels of CA 15-3 tend to be elevated during pregnancy and lactation.

What are the risks involved?

A cancer antigen 15-3 test is a blood test. It is easy to perform, safe and quick test. Complications are rarely seen. However, as this test involves the puncture of a vein to collect a blood sample, the following complications may arise-

– You may feel a stinging sensation when the needle pricks your skin.

– The act of puncturing a vein and drawing blood may be unnerving to some. You may feel dizziness at the sight of blood. It is advisable to distract yourself during this step if you are faint-hearted.

– A bruise at the sight of the prick may appear.

– In some cases, bleeding may be encountered at the site of venous invasion.

– A hematoma may form at the site of puncture.

There are chances of infection at the site of venesection at a later stage. If you encounter the presence of pus or signs of inflammation at the site, consult your physician.

What are the contraindications of a CA 15-3 test?

There are no absolute contra-indications to a CA 15-3 test. However, as it is a blood test including venesection, your physician may defer performing this test if you suffer from a bleeding tendency.

How should I prepare for a CA 15-3 test?

No specific preparations are to be done by you before embarking on a CA 15-3 test. However, you need to inform your physician about your medical history, and any medicines or supplements that you might be consuming at the time of the test. Inform him if you suffer from any coagulopathy or are on blood thinners. You also need to intimate your physician if you are pregnant or breastfeeding your child. The levels of CA 15-3 tend to get elevated in women who are pregnant or lactating.

How is a CA 15-3 test performed?

It is a blood test carried out on an outpatient basis unless you are already admitted in a hospital. A laboratory technician will escort you to the assigned place to collect blood sample for the test. The laboratories usually have designated collection points for retrieving samples for a test. The CA 15-3 test is easy to perform and consists of the following standard steps

– The technician will apply a tourniquet proximally to the site chosen for venipuncture. This makes the veins more prominent, allowing easier access. The median cubital vein (a superficial vein on the inside of your elbow) is commonly chosen.

– The area is cleaned with a disinfectant.

– A sterile, single use needle is used to puncture the vein and draw about 5 ml of blood.

– Pressure is applied to the vein with a sterile gauze after the needle is withdrawn. It stops bleeding at the site of puncture.

-Tourniquet is released.

– The blood sample is collected in a vial.

How long does the CA 15-3 test take?

The entire procedure is over in 5-10 minutes. In obese patients, and patients belonging to geriatric age group, venous access is sometimes difficult, leading to more than one prick. The time taken to collect a blood sample may get prolonged in such cases.

When can I get the results of a CA 15-3 test?

You can get the results of a CA 15-3 test on the same day (within 24 hours in some cases).

What do the results convey?

The reference range of serum CA 15-3 is less than 30 U/mL. Different laboratories use different methods to test for this antigen. So, if you are going for serial testing, it is advisable to stick to a single laboratory.

– A declining level of CA 15-3 indicates that the malignancy is responding to treatment.

– The higher the CA 15-3 levels, the more widespread is the breast cancer.

– As the tumor burden grows, so does the concentration of CA 15-3 in the blood.

– An increasing level of CA 15-3 antigen may also indicate that the anti-cancer therapy is not working. A stable value indicates that the tumor is not growing.

– A false high reading may be obtained if the test is performed too early during treatment.

What is the cost of undergoing a Cancer antigen 15-3 test in India?

The cost of a CA 15-3 test in India ranges from Rs 1000-1500. The actual cost may vary depending on the city you reside in and the diagnostic center that you choose for this test.

What are the advantages and limitations of a CA 15-3 test?

Advantages Limitations
It is a safe, easy to perform and quick test. It can be safely performed in pregnant and lactating women.It has low sensitivity in early-stage breast cancer.
The sensitivity and specificity are high for metastatic breast cancer.It has no clinical significance in breast cancers that do not secrete CA 15-3 tumor marker.
It can be used as an independent prognostic factor for patients of breast cancer.A falsely elevated result may be obtained in the first 4-6 weeks of therapy.
Any recurrence of breast malignancy can be detected well in advance (5-6 months) of any other sign/symptom or other tests.The overall sensitivity and specificity of CA 15-3 for all breast cancers are low. It needs to be supplemented by other tests in order to reach a conclusion.

Want to live a healthy lifestyle?

Subscribe to free FactDr newsletters.

REVAMP YOUR

If you're enjoying our website, we promise you'll absolutely love our new posts. Be the first one to get a copy!

Get factually correct, actionable tips delivered straight to your inbox once a week.

I want the latest scoop on :

We hate spam too. We will never share your email address with anyone. If you change your mind later, you can unsubscribe with just one click

By clicking Subscribe, I agree to the FactDr Terms & Conditions & Privacy Policy and understand that I may opt out of FactDr subscriptions at any time.

 

 

 

Related Posts

Trending Topics

ASTtest-liver
AST- Aspartate Aminotransferase Test AST test is a blood test that is used to measure the level of a…
Ferritin blood test
Ferritin Test Ferritin test is a blood test that provides vital information on the level of RBCs…
Vitamin K2: 8 reasons why you need this bone-building & cancer-fighting nutrient Vitamin K2 is claimed to be essential for your bone health, for reducing the risk…
passion fruit juice
Passion fruit: How one exotic fruit can help you fight infections and cancer! Passion fruit: Why does this exotic fruit have such an enticing name? And how can…
anti-thyroglobulin antibody
Anti-Thyroglobulin Antibody test Anti-thyrogloubin antibody test measures the level of antibodies that attack the thyroid gland cells and…
Maltitol: Things you must know about this artificial sweetener Sugar alcohols are produced by fruits and vegetables. Maltitol is an artificially produced sugar alcohol…
TBHQ: A carcinogen lingering in your child’s favorite snacks TBHQ - Why you should shun the practice of eating instant noodles or microwave popcorn…
folate test
Folate test The Folate test is used to measure and monitor the levels of folic acid in…
hlab27 test
HLA-B27 test The HLA-B27 is a blood test that is used to determine the level of a…
Lectin: The common link of proteins between peas and people Lectins are a type of protein that are found majorly in legumes. Most people are…
rubella IgG test
Rubella IgG Test The rubella IgG test is a blood test that checks for the rubella virus IgG…
The real reason why you shouldn’t be eating ramen noodles Instant ramen noodles might be your go-to snack for your hunger pangs. But with each…
Pulmonary Function Tests Pulmonary function tests (PFT’s) are non-invasive breathing tests employed for diagnosing and monitoring lung diseases…
low fodmap plan
Troubled with IBS? Here’s a complete roadmap to the low FODMAP diet Leaky & inflammatory gut troubling you? No medicine bringing you relief from the pain? Why…
abdominal-CT-scan- image
Abdominal CT scan Abdominal CT scan is a diagnostic imaging technique that provides a clear picture of the…
Top 6 remedies to treat a razor burn at home Symptoms of razor burn include bumps on the skin, redness, and irritation of the skin.…
serum electrolyte test
Serum Electrolyte If there is an electrolyte imbalance in the body, a serum electrolyte test will help…
Stye : The best natural home remedies to ease the pain Styes developing inside the eyelid tend to be more painful whereas external styes are less…
BRAT Diet: What is the right way to follow this diarrhea-relieving diet? BRAT diet, a simple diet consisting of just bananas, rice, applesauce, and toast, can help…
cardiolipin antibody igm
Cardiolipin Antibody (ACL) –IgM Test The types of cardiolipin antibodies are the IgG, IgA and IgM types and this particular…
How do neutrophils protect you from fatal bacterial attacks? During an infection, certain enzymes alert the mature neutrophils.  Neutrophils then travel through the bloodstream…
The science behind daith piercing: Can it really cure migraine? Since the ear has several pressure points, it is believed that daith piercing activates the…
diverticulitis diet
Diverticulitis diet: The right way to eat if you suffer from the disease Are you suffering from diverticultis but clueless about your diet ? Read this complete plan…
cytomegalovirus iGG
Cytomegalovirus (CMV)- IgG Test The cytomegalovirus IgG is the immunoglobulin protein produced by our immune system when the body…
Chromium Picolinate: An essential mineral supplement for faster weight loss Did you know that about 1.6 million deaths were directly linked to diabetes globally? How…
maltodextrin sugar
Maltodextrin: What are the hidden health benefits of this food additive? Maltodextrin is one of the few food additives that has been relatively deemed safe. Many…
Chlorella: Therapeutic powers of the billion-year-old algae now within your reach Chlorella - A billion year old nutrient-rich algae that can potentially ward off cancers and…
IGE test
IgE test – Immunoglobulin E IgE or immunoglobulin E test is a test that measures the level of IgE in…
RHEUMATOID_FACTOR_(RF)
Rheumatoid Factor (RF) Rheumatoid factor or RF is a blood test used to diagnose painful joint conditions such…
dance health benefits
5 unbelievable effects of dance on your overall health! You enjoy dancing, but did you know what else it does to your body? Dancing…
beta 2 glycoprotein 1 IgG
Beta 2 Glycoprotein 1 IgG Beta 2 glycoprotein 1 antibody test involves detecting and measuring the presence of the IgG…
Silicon Dioxide: How can a component of sand be essential to your wellbeing? Silicon is one of the most abundant elements in the nature. Find out how silicon…
TPAB test
Treponema Pallidum Antibody(TPAB) test Treponema pallidum bacteria a gram-negative bacteria that has helically coiled, corkscrew-shaped cells, responsible for STDs…
Piaget stages: Do they accurately describe the way the human brain develops?  A common assumption was that children are less competent thinkers as compared to adults, but…
Rubella IgM test
Rubella IgM Test The Rubella IgM test is a blood test that is performed to diagnose the presence…
vdrl test syphilis
VDRL Test The VDRL test is a blood test that is used to diagnose sexually transmitted or…
Quinine: How gin and tonic came to be known as a potent health elixir The discovery of quinine-containing tree bark is sometimes considered the most serendipitous medical discovery of…
lipid-profile
Lipid Profile Lipid profile is a blood test that provides complete information on how much cholesterol is…
BoneMarrow-Biopsy
Bone Marrow Biopsy Bone marrow biopsy is a diagnostic procedure where a small amount of bone marrow is…
serum zinc test
Serum Zinc Test The serum zinc test is a blood test performed to assess the zinc level in…
occupational hazards types
Occupational Hazards: How to vouch for your health at your workplace Occupational hazards affect millions worldwide. Chemical spills, faulty wires, deadly pathogen, and work-stress can happen…
lipoprotein A
Lipoprotein (A) Test Lipoprotein (A) test is used to measure and monitor the levels of LDL(Low-Density Lipoprotein) in…
How accurate is the hair follicle drug test? Hair follicle drug test is one of the best ways to identify drug use in…
Poop chart: Top things you didn’t you your poop could reveal about you Bristol poop chart was designed during the 1990s in order to help doctors identify various…
POSTPRANDIAL-BLOOD-SUGAR
Post-Prandial Blood Sugar Postprandial blood sugar test is an important diabetes diagnosing tool. This simple blood test measure…
bilirubin-test-result
Bilirubin Test Bilirubin is a substance produced in the body as a result of red blood cell…
Bloodtestalbumin
Albumin Test Albumin test or blood serum test is a liver function test that measures the amount…
Helicobacter pylori IGA
Helicobacter Pylori – IgA Test The H.pylori IgA test is a blood test used to identify the level of IgA…
Free T3 test
Free Triiodothyronine (FT3) Test The free triiodothyronine or FT3 test is an important blood test that is used to…
random blood sugar test
Random Blood Sugar Test The random blood sugar or RBS test is a blood test prescribed mainly to check…
lifestyle diseases
The Big 5 lifestyle diseases: How your everyday living might be killing you You'd be shocked to know how unhealthy and potentially fatal your everyday routine could be.…
CLA: A breakthrough weight loss supplement with minimal side effects Tried every weight loss supplement in the market with no substantial gain? Why not try…
Chest X-Ray A chest x-ray is a diagnostic test that uses x-rays to visualize the structures inside…
hidden benefits walking
9 benefits of walking we bet you didn’t know! Did you know walking can be the miracle pill for eternal youth? Everyone knows walking…
Kava: Is it the healthy substitute for alcohol you have been waiting for? Native to the beautiful South Pacific islands, Kava is a famous beverage rooted in the…
HELICOBACTER_PYLORI---IgG
Helicobacter Pylori – IgG Test Helicobacter pylori IgG test is a blood, saliva, and urine test performed to determine if…
shiitake mushrooms healthy
What are Shiitake Mushrooms and why should you eat them? Shiitake Mushrooms are well known for their smoky and robust taste. However, did you know…
green poop causes
Green poop : What are the reasons and how can you correct it Ever sneak a peek down the toilet only to shockingly find green poop? Why does…
eating disorder anorexia
Eating Disorders: Lifestyle choice or a psychological condition? Is eating disorder just a harmless bad habit? Or does it represent grim psychological disorders?…
Milk Thistle skin
Milk Thistle: Find possible cures for fatal diseases in these purple blooms Milk thistle is well-known for treating liver conditions. However, did you know that it comes…
Juice Plus: Can you really replace actual fruits with pills?  Juice Plus supplements intend to fill nutritional gaps present in our daily diet. But how…
Trisodium Phosphate: How a paint thinner made its way into your breakfast Ever thought how toxic chemicals find their way into our foods? How can they harm…
Tamarind: The top health benefits of this staple Asian ingredient Did you know this sweet and sour pulpy fruit does more than just add a…
EEG
Electroencephalogram – EEG EEG or electroencephalogram is a diagnostic tool used to access the functioning of neurons and…
blood elements analysis
Blood Element Analysis Test A blood element analysis is a blood test performed to measure the level of toxic…
Jicama: A fiber-rich tuber for your weight loss goals Pronouced as HEE-kah-ma, Jicama is the "new kid on the block" that has taken the…
carrageenan seaweed
Carrageenan: How a simple seaweed extract could better your gut health & immunity Eat more ice cream to prevent cold and flu? –With carrageenan you get one simple…
Moringa drink
Moringa: This could be the most nutrient-dense food known to us! Moringa is a lush green tree brimming with over 90 essential nutrients required for a…
GM Diet: The fastest way to lose weight or yet another hoax diet? General Motors started this trend of extreme dieting for 7 straight days to ensure its…
EMA antibodies
Endomysial Antibodies (EMA) Test EMA test is an investigative blood examination to locate the presence of certain antibodies, called…
autoimmune diseases facts
Autoimmune Diseases: Find out if your body is attacking you right now Did you know your body can harm itself? What are autoimmune diseases and why does…
nutritional yeast bread
Nutritional Yeast : How can a fungi culture be good for your body? Nutritional yeast: How a simple culture of fungi can transform your skin, digestion, immunity ,…
Coffee Enema: Turn your favorite morning beverage into a powerful colon cleanser The wonders of coffee are not just limited to waking you up every morning. You…
ketoacidosis diabetes
HB1Ac Test HB1Ac test is an important blood test that is used to measure the levels of…
fructosamine test
Fructosamine Test A fructosamine test is a blood test that measures blood sugar glucose content. Fructosamine level…
helping friend with depression
Support and care tips for helping people with depression Read to find out what is depression, its causes and symptoms. Also check out the…
improve digestion weight loss
Power up your gut: 8 proven steps on how to improve your digestion Did you know you have a colony of bacteria in your gut that help you…
Jackfruit: Slice your way into higher immunity, better digestion, & more… Native to the South East Asia, the jackfruit is a fruit brimming with thousands of…
Colloidal silver benefits
Colloidal silver: An essential dietary supplement or yet another pharmaceutical hoax? Colloidal silver is hailed as an effective home remedy for infections. Many believe it can…
Eustachian Tube : Functions and top home remedies to prevent its infection Pressure equalization, mucus drainage and protecting the middle ear from bacteria and viruses are the…
SIBO Diet: The important dos and don’ts of this gut-healing diet A SIBO diet is a diet that works by eliminating certain sugars from your diet…
How seitan proved to be a blessing in disguise for vegans worldwide Can only meat-eaters enjoy delicious juicy steaks and burgers? With seitan, the best meat substitute…
CT-scan-machine
CT – Computed Tomography Scan CT scan or computed tomography scan is an diagnostic imaging technique where cross-sectional images of…
Anti-CCP Test – Anti-Cyclic Citrullinated Peptide Anti-ccp or ACCP test is a blood test that is primarily employed to diagnose the…
DHEAS test
DHEA Sulfate (DHEAS) Test DHEAS or DHEA Sulfate test is prescribed if an individual shows symptoms of abnormal adrenal…
shakeology woman
Meal replacement or protein drink? Learn all about Shakeology and its claims Shakeology from Beachbody claims to be the most suitable shake that can aid in weight…
beta hcg test
Beta hCG Test A Beta hCG test measures the level of human gonadotropin hormones present in the blood…
thyroglobulin test
Thyroglobulin (TG) Test Thyroglobulin test helps in measuring and monitoring the concentration of thyroglobulin. The thyroglobulin test can…
bananas exercise
10 health reasons why you should go “bananas” over bananas! Bananas:The world's most popular fruit comes with a host of unbelievable health benefits. Find out…
Did you know drinking alkaline water could be the healthier choice for you? Ever wondered how safe is your drinking water in terms of pH? Recent studies have…
Pescatarian Diet 101: What are the inherent health advantages of this diet? People opt to become a pescatarian in order to enrich their bodies with the essential…
free thyroxine ft4
Free thyroxine test (FT4) The FT4 or free thyroxine test is a blood test used to detect the level…
beta 2 glycoprotein 1 igm
Beta 2 Glycoprotein 1 IgM The Beta 2 glycoprotein 1 IgM test detects IgM class of antibodies in the blood.The…
Panera bread steak arugula
Panera Bread: The truth behind this “healthy” restaurant chain What to order and what to avoid when dining at Panera Bread ? Know more…
Horny Goat Weed: Can it improve libido in human beings too? This plant got its name as Horny Goat Weed when one of the goats feeding…
What to eat, what not to eat in the South Beach Diet? The South Beach Diet is one among the most popular weight loss programs that have…
waterchestnut
Water Chestnuts: The tastiest ways to include this healthy tuber in your diet Water chestnut is not a nut after all. It is a tuber (much like the…
Hydroquinone: Is it the best topical treatment for hyperpigmentation? Darkening of the skin due to high melanin levels is called hyperpigmentation.  Hydroquinone interferes with melanin…
Microneedling: Does this cosmetic procedure live up to the hype? Is microneedling a safe and painless procedure? How can pricking your skin with a series…
EMG electromyography
EMG- Electromyography EMG detects the presence, location, and extent of diseases that damage the nerves such motor…
ANTI-MICROSOMAL-ANTIBODY-(AMA)
Anti-Microsomal Antibody AMA Test AMA or anti-microsomal antibody test is a blood test that measures the activity of AMA…
liver detox facts
7 liver detox facts and why ignoring these could kill you! Are you taking care of this organ that handles over 500 different vital functions in…
These are the top foods to increase your hemoglobin count It is important to add iron-rich foods into your diet in order to increase hemoglobin. Deficiency…
Internal bleeding brain
Beware: Ignoring these tell-tale signs of stroke could cost a life The signs and symptoms of a stroke differ depending on which part of the brain…
CBC blood test
CBC (Hemogram 6-part diff) blood test CBC (Hemogram 6-part diff) blood test refers to the test that measures the number of…
Bronchoscopy procedure
Bronchoscopy Bronchoscopy is a procedure where in a scope is inserted into the lung pathway to…
Pumpkin Seeds: Why pumpkins are more than just for pies! Pumpkins have been long associated with Halloween carvings and delicious pies. But did you know…
xylitol gum
Xylitol : Is this the right sugar substitute for you? Discovered during World War 2 owing to sugar shortage, xylitol has become a common name…
Cordyceps: How the Caterpillar fungus works as a proven cancer-shield Strange as it may sound, but cordyceps or "caterpillar fungus", a fungus variety native to…
Is bronchitis contagious? And how to prevent this infection? It is acute bronchitis that is contagious which means you can contract it from another…
How to scrub away stress and fatigue with an Epsom salt bath? Epsom salt is a popular home remedy for many skin ailments. Though there is a…
reflexology massage
Top reasons why you should go for a reflexology massage today Reflexology involves the application of pressure to your feet and hands to encourage self-healing. Could…
Cystoscopy Cystoscopy is intended to look at the abnormalities in the ureters, bladder, and urethra, to…
Amaranth: Why is this native Peruvian grain called the “crop of the future”? Full of healthy high proteins and gluten-free, the grain, Amaranth, the tasty and ancient pseudo…
Garlic health benefits cloves
Garlic: Nature’s white pill as an effective home remedy What are the secrets hidden in these tiny white pills? Find out the immense health…
Find all the instant ways to get rid of blackheads Blackheads - Not only are they aesthetically unappealing but if left untreated these can cause…
Top reasons why you need to pay attention to your vitamin B6 intake Vitamin B6- An essential water-soluble vitamin. Its deficiency leads to physical changes such as sores…
Hot cups for detox? Read all about the ancient technique of cupping Did you know inverted hot cups on your back can squeeze out and eject toxins…
tonometry
Tonometry Tonometry uses a device called tonometer to measure the pressure inside the eye. This pressure…
GGt test
GGT – Gamma-Glutamyl Transferase Test GGT or gammaglutamyl transferase test is a liver function test that is used to detect…
Vitamin-D-blood-test
25-Hydroxy Vitamin D test 25-hydroxy Vitamin D test is a blood test used to measure the level of vitamin…
Okra: How can this nutrient-dense vegetable help you fight diabetes? Okra is a food which is rich in nutrients and minerals which are extremely essential…
fitness routine fun
10 fantastic ways to make your fitness routine more fun! Are you too bored to exercise? Do you avoid gym cause it's too monotonous? Looking…

Related Posts

Want to live a healthy lifestyle?

Subscribe to free FactDr newsletters.

REVAMP YOUR

If you're enjoying our website, we promise you'll absolutely love our new posts. Be the first one to get a copy!

Get factually correct, actionable tips delivered straight to your inbox once a week.

I want the latest scoop on :

We hate spam too. We will never share your email address with anyone. If you change your mind later, you can unsubscribe with just one click

By clicking Subscribe, I agree to the FactDr Terms & Conditions & Privacy Policy and understand that I may opt out of FactDr subscriptions at any time.