Sepsis (Blood Poisoning)

septic wound

Last Updated October 23rd, 2019

Introduction

Protecting the internal organs and tissues from the invasion of pathogens and toxic substances is vital to ensuring the body’s survival and good health. There are several mechanisms that ensure this. For instance, clotting not only prevents the loss of blood but also plugs wounds so that infectious agents and other unwanted substances cannot enter the body by that route. Locating and destroying pathogens is the main function of the immune system. It uses methods such as inflammation in order to neutralize threats like bacteria or viruses.

Sometimes, however, the immune system itself can be responsible for problems within the body. For instance, autoimmune disorders occur when the immune system mistakenly targets healthy cells of the body instead of external agents. Sepsis or blood poisoning is another possible scenario in which an immune response becomes the cause of a major health problem.

What is Sepsis?

sepsis woundSepsis, septicemia, or blood poisoning is a life-threatening condition which can arise as a complication of infection. Certain chemicals released by the immune system aid in fighting and destroying pathogens when infection is detected. At times, these chemicals enter the bloodstream in such large quantities that they can end up circulating throughout the body and causing inflammation in various organs and tissues. Medical practitioners recognize three stages in the progression of this condition. These are sepsis, severe sepsis, and septic shock, respectively. As the condition escalates, the organs are directly affected as a result of restricted blood supply and may begin to fail, unless treatment is commenced.

What is the Mechanism that Leads to Sepsis?

Generally, the immune system attempts to ensure that an infection remains localized and does not spread to the other parts of the body. It deploys antibodies to help neutralize pathogens and also produces inflammation at the site of infection. When, despite these measures, pathogens manage to spread further into other areas, the immune system becomes overwhelmed and goes into overdrive in an attempt to restrict the infection. This ends up causing widespread inflammation throughout the body. It can damage the tissues and cut off blood supply to vital organs such as the brain and kidneys. This is responsible for organ failure and eventual death in the absence of timely intervention.

Who Is Likely To Develop This Condition?

SEPSIS (BLOOD POISONING)The direct cause of sepsis is an infection, whether bacterial, fungal, viral or parasitic in nature. Risk factors include:

  • Any kind of infection, whether a minor localized one or a severe infectious disease such as pneumonia can be responsible for triggering sepsis.
  • Being pregnant is a risk factor.
  • Having a long-term medical condition such as diabetes is also a risk factor.
  • The risk of infection leading to sepsis is higher in individuals with weak immunity. Newborns, for instance, have not yet developed adequate immunity. Individuals who are advanced in age are also likely to have weaker immunity, making them more susceptible to infection, and by extension, conditions such as sepsis. Those suffering from immune deficiency or HIV infection are also at a higher risk. Patients recovering from severe illness or surgery and those taking immunosuppressant medications as part of organ transplantations also have weakened immunity.
  • Those who have sustained major injuries such as extensive burns also tend to be susceptible to developing sepsis.
  • Individuals on artificial respiratory support, dialysis, intravenous tubes or catheters are at risk of contracting the infection through these devices.

Signs of Sepsis

Initial symptoms include:

  • Alternatively, the patient may have a low body temperature.
  • Chills.
  • Elevated heart rate.
  • Rapid breathing.
  • Nausea and vomiting.
  • Diarrhea.

Signs of Severe Sepsis and Septic Shock

Severe sepsis is the outcome of damage to organs as a result of reduced blood supply. The patient is deemed to be in a state of septic shock when, in addition to some of the symptoms listed below, their blood pressure begins to drop critically. This can rapidly lead to multiple organ failure.

  • Nausea and vomiting.
  • Clammy or mottled skin
  • Reduced urine production.
  • Slurring of speech.
  • Severe breathlessness.
  • Loss of cognition.
  • Falling platelet count.
  • Difficulty in breathing.
  • Abnormal cardiac signs.
  • Reduced body temperature.
  • Loss of consciousness.
  • Severe fatigue.

How Is It Diagnosed?

septic woundPrompt diagnosis and commencement of treatment are crucial in cases of sepsis. The condition can thus be prevented from escalating and damage to vital organs such as the brain, heart or liver can be restricted if not entirely prevented. Usually, blood tests, body temperature, heart rate and rate of respiration provide indications of sepsis. Blood, urine and other bodily fluids are examined for infection. Testing may also take into account wound secretions and respiratory secretions wherever applicable in order to determine the nature of the pathogen.

Imaging tests such as X-rays, ultrasounds and computerized tomography (CT) help clarify the extent of damage to organs. There may be several other specialized tests depending on which organs have been impacted. For instance, liver function tests or electrocardiograms may be required. Those diagnosed with severe sepsis will need to be kept in intensive care and their vitals will be closely monitored.

Treatment

  • Antibiotics are prescribed to remove the bacteria from the system.
  • In cases of severe sepsis, medications to help restore blood pressure blood sugar will be given.
  • Supportive care will be provided if the patient is unable to breathe on their own, and dialysis may also be given, depending on the severity of the patient’s condition.
  • In severe cases, surgery to remove the infection or abscess from the body will be conducted.

Prevention 

There are certain risk factors that can help delay the onset of the infection

  • Get a regular check-up done if you are above the age of 60 years.
  • Strengthen your immune system.
  • Do treat all injuries properly and avoid any infections.
  • Take your medications on time.

Facts

  • 20-30 million cases of sepsis are reported each year worldwide.
  • Sepsis is one of the leading cause of death in the case of hospitalized patients in the USA.

Facts

  • Every day, 38 patients are amputated worldwide owing to sepsis.
  • Septic shock is said to have the highest mortality rate among non-coronary ICU patients

Facts

  • Sepsis causes more deaths than prostate cancer, breast cancer and HIV combined.

Related Conditions

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Dos and Don'ts

Dos
  • Ensure that you get a check-up done even if you are mildly sick, to avoid complications.
  • Consume immune system strengthening foods, this helps in providing the body with necessary nutrients.
  • Get a check up done regularly, in case of any infections or if you are above the age of 60 years.
Don'ts
  • Take any injury lightly, as they can lead to sepsis.
  • Ignore hygiene if you have a catheter or breathing tube attached to you, this can lead to infection in the area and therefore sepsis.
  • Ignore your health, if you visit the hospital frequently, knowing the level of your immune system and trying to strengthen it can help reduce the symptoms of this condition.

 

 

 

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Appendix pain: Recent findings on this not-so vestigial organ The exact function of the appendix is still not clear. Some consider it as an organ that once…
How to scrub away stress and fatigue with an Epsom salt bath? Epsom salt is a popular home remedy for many skin ailments. Though there is a lack of scientific…
SIBO Diet: The important dos and don’ts of this gut-healing diet A SIBO diet is a diet that works by eliminating certain sugars from your diet and adding fibers…
Coffee Enema: Turn your favorite morning beverage into a powerful colon cleanser The wonders of coffee are not just limited to waking you up every morning. You can now use…
GGt test
GGT – Gamma-Glutamyl Transferase Test GGT or gammaglutamyl transferase test is a liver function test that is used to detect the extent of…
thyroid_scan
Thyroid Scan Thyroid scan is a diagnostic procedure that aims to view the thyroid gland and detect any growths or…
quinoa salad
Quinoa : A prodigious superfood you need to include in your diet today! Quinoa - what is so special about this native South American grain that has taken the world by…
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L-Theanine: Better sleep, higher focus, and many other benefits Did you know that L-theanine found in green tea can make you sleep better and be focused at…
improve digestion weight loss
Power up your gut: 8 proven steps on how to improve your digestion Did you know you have a colony of bacteria in your gut that help you in digesting food?…
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10 health reasons why you should go “bananas” over bananas! Bananas:The world's most popular fruit comes with a host of unbelievable health benefits. Find out how you can…
ashwagandha brain
Ashwagandha: The best-kept secret of Ayurveda now revealed! Ashwagandha literally means "smell of horse". Don't get bogged down by that one tiny detail because this ayurveduic…
The complete “what to eat” guide for gluten intolerance Does eating breads and pastas often makes you nauseous? Gluten intolerance is a common reason why you might…
Oxalates: How healthy greens can sometimes be bad news for your kidneys Oxalates are compounds present in a majority of healthy foods. However, at times an overconsumption of these could…
Inversion Therapy: The anti-gravity way of healing chronic back pain Inversion therapy involves suspending a person upside dow using different types of equipment. This works by taking the…
Bubble Tea: Bubbling with nutrition or a hidden sugar mine? The tapioca pearls present in the tea looks like bubbles and hence the name bubble tea became popular.…
vdrl test syphilis
VDRL Test The VDRL test is a blood test that is used to diagnose sexually transmitted or venereal diseases, primarily…
complement c4 test
Anemia Profile Anemia Profile test (Basic) is a blood screening test that measures the levels of important components of the…
shoudler exercises
Keep your shoulders pain-free with these shoulder exercises Shoulder exercises are important in order to prevent chronic back and neck pain. Learn more about how you…
sugar toxic health
Sugar: 7 new shocking truths revealed about the sweet poison Can drinking soda bring you closer to death? Is sugar slowly poisoning you and your family? You would…