Nurokind LC

Therapeutic Indications

Nurokind LC is a medication in tablet form that is used as a dietary supplement for nutritional deficiencies. It contains folic acid, levocarnitine, and methylcobalamin. Nurokind LC is used for the treatment and management of the following symptoms, conditions, and diseases:

• Levocarnitine deficiency( secondary and primary)
• Muscle spasms
• Vitamin B 12 deficiency
• Megaloblastic anemia due to folic acid and vitamin B12 deficiency.

• 

  Peripheral neuropathy that causes pain and numbness occurring in the legs and hands.
• Pernicious anemia
• Folate deficiency in pregnancy
• Alcoholic neuropathy
• Diabetic neuropathy
• Malabsorption of nutrients
• Nerve damage
• Tingling and numbness
• Conditions of the heart affecting children and infants
• Poor diet
• Anemia due to lack of folic acid
• Valproate toxicity
• Used for providing nutritional requirements if you are having renal dialysis, or have heart diseases and liver disease.
• Diarrhea
• Reduced muscle mass

Nurokind LC is prescribed for various problems including anemia, diabetic neuropathy, and vitamin B12 deficiency. Therefore it is recommended to get yourself checked to determine the underlying cause of your symptoms.

We provide the option for you to book various blood tests from the comfort of your home. It is advisable to take tests such as the CBC blood test, vitamin B12 blood test, and post prandial blood sugar to check your blood component levels. This will also help you monitor your progress.

Do I Need a Prescription?

Nurokind LC can be bought from pharmacies close to you and online drug stores. But a doctor’s prescription is mandatory.

Dosage

The dose and duration of use of Nurokind LC depend on the medical condition being treated, your weight and age. The recommended dosage of Nurokind LC for some conditions is:

• Megaloblastic anemia due to deficiency of vitamin B12. 500 mcg once a day three times in one week. After two months of using, the dose is reduced to 500 mcg after every 1-3 months as a maintenance dose.
• Peripheral neuropathies. 500 mcg once a day three times in a week if administered intravenously or intramuscularly. If orally, 500 mcg three times a day.

Chemical Composition

Nurokind LC contains three active ingredients. The ingredients include:

• 5 mg Folic acid
• 500 mg Levocarnitine
• 1500 mcg Mecobalamin/Methylcobalamin

Nurokind is manufactured as a tablet and as an injection, thus can be administered orally, intravenously and intramuscularly.

Mechanism of Action (MOA)

Levocarnitine is usually synthesized by the body, but in some cases, the body does not manufacture enough. Taking Nurokind LC will compensate for the fewer amounts produced. Levocarnitine is important in the transportation of long chain fatty acids into the mitochondria for energy production. It is also used in the removal of acyl groups from cell organelles before they accumulate to toxic levels.

Methylcobalamin is commonly called vitamin B12. It is essential in the repair of nerve tissues and ensures they properly function. Nurokind ensures your body gets enough amount for vitamin B 12 to main these functions.

Folic acid is Vitamin B 9. It is vital in the production of healthy and mature red blood cells. It prevents changes or mutations in your DNA enabling the body to produce new cells.

Contraindications

The use of Nurokind LC is contraindicated if you are suffering from some medical conditions. When used Nurokind LC can worsen the medical condition or result in adverse reactions occurring that may be fatal. Before you begin using Nurokind LC, inform your doctor of all medical conditions, diseases, and disorders you have including your family medical history as they could affect your prescription. The following conditions are contraindicated for the use of Nurokind LC:

• Allergic reaction: Do not take Nurokind LC if you are allergic to any of the active ingredients.
• Levocarnitine may interfere with the functioning of the thyroid hormone.
• Levocarnitine may increase the seizures and their severity
• Liver disease
• Renal impairment: It could cause hyperkalemia
• Pregnant or planning to be pregnant. Nurokind LC should be used with cautions. Although studies from animals have shown adverse effects on the growing fetus, there are not enough human studies to be conclusive. It should be used with caution when the benefits outweigh the risks.
• Breastfeeding mothers should use the medication with caution.
• When using blood thinners
• Leber’s disease

Side effects

Medications can cause side effects apart from the intended results. Nurokind LC has some side effects; the side effects do not occur in everyone. They depend on the dosage, duration of use and individual response to the medication. The side effects can be common and less serious and sometimes go away as you continue using the medication while, others can be serious and rare. Report to your doctor any side effects you experience, especially if they do not go away to get medical advice on how to manage the side effects.

The following are the common side effects of Nurokind LC:

• Vomiting
• Headache
• Nausea
• Diarrhea
• Loss of appetite
• The weakness of the muscles
• Distension of the abdomen
• Altered sleep patterns or sleep disturbances
• Flatulence
• Cramps in the abdomen
• Bitter tongue
• Irritation
• Paresthesia
• Hot flashes
• Nail disorder
• Loss of hair
• Garlic breath
• Injection point pain
• Pain in the bones

Serious and rare side effects include:

• Depression
• Confusion
• Seizures
• Tachycardia
• Uncontrolled vomiting
• Reduced blood sugar levels

Nurokind LC use should be discontinued immediately if you have an allergic reaction to the medication. Signs of an allergic reaction include rashes on the skin that may be itchy, flaking of skin, sore lips and mouth, boils, difficulty breathing, wheezing, collapse, swelling of the throat, lips, tongue, tongue, and coughing.

If you accidentally take an overdose of Nurokind LC, immediately inform your doctor or rush into the emergency center of the nearest hospital carrying the medication package with you for identification. An overdose could cause an awful reaction to the medication. Overdose symptoms include tightness of the chest, rashes, itching, fever, persistent coughing, skin color turning grey or blue and seizures.

Facts on Nurokind LC

• After administration of Nurokind LC, its peak effects occur after three hours.
• The duration of caution of Nurokind LC is prolonged due to the active ingredient being already present in the body.
• Folic acid is well absorbed from the small intestines having 0.016- 0.021 mcg/ml of serum.
• 40% – 80% of Mecobalamin is secreted through urine during the first eight hours after administration.
• Nurokind LC should be used with caution in expecting women as it has shown adverse effects in animal studies.
• Nurokind LC can result in slight addictive tendencies.

Drug interactions

Taking more than one medication together can result in drug interactions. Drug interactions change the way your medications work or may interfere with their uptake in the gastrointestinal tract or cause accumulation of some of the medicines in the body that may end up causing adverse reactions of the medication. Inform your doctor of all medications you are using or have been using previously, both over the counter drugs and prescription drugs, dietary supplements and herbal products as they may interact with Nurokind LC. The doctor may adjust your dose in some cases and advice you on how to take the medications to avoid them interacting.  The following drugs and products interact with Nurokind LC:

• Primidone
• Tetracycline
• Pivampicillin
• Pivcephalexin
• Chloramphenicol
• Concurrent use may cause excess calmness and drowsiness. It can also result in reduced blood pressure, pain in the chest, flushing and an increase in heartbeat.
• Diphenylhydantoin
• H2 blockers
• Proton Pump Inhibitors(PPI) such as omeprazole
• Barbiturates
• Nitrofurantoin
• Phenytoin
• Aminosalicylic acid
• Warfarin
• Colchicine
• Methotrexate
• Dicoumarol
• Neomycin
• Oral contraceptives. Nurokind LC may lower their levels in serum

What to Do If You Skip a Dose?

If you skip a dose, take it as soon as you realize it. If it is close to the time for your next treatment, you can skip it and take your next dose then continue with the normal drug routine. However, do not double your dose to compensate for the skipped dose as it might cause adverse reactions. Frequent skipping of your medication makes the drug less effective in treating your condition. Set the alarm or have a family member remind you when it is time for your next dose to avoid missing doses.

Precautions

Some precautions should be considered before and while using NurokindLC. The precautions include:

• Hypersensitive reactions. Do not take Nurokind LC if you are allergic to the active ingredients in the medication.
• Inform your doctor of all medical conditions you have or have had before to prevent adverse reactions to the medication occurring.
• Inform your doctor of all medications and products you are using to prevent drug interactions from occurring and ensuring your medications works in the correct manner.
• Avoid consumption of alcohol while using Nurokind LC.
• Taking doses of folic acid above 0.1 mg daily may interfere with the diagnosis of pernicious anemia.
• Nurokind LC should be used with caution if you have kidney disease or liver disease.
• The benefits and risks should be weighed when using Nurokind LC if you are expecting or planning to conceive as animal studies have shown it may harm the growing fetus.
• Do not use Nurokind LC if you have a family history of seizures.
• If you experience a headache and drowsiness while using Nurokind LC, do not take part in activities that require mental alertness like driving and operation of heavy machinery.
• Do not take Nurokind LC that has expired. Expired medication has reduced effectiveness. Always check the medication package for expiry date as you purchase it.
• Nurokind LC should be stored at room temperature away from heat and direct sunlight; it should not be frozen.
• It is advised to take Nurokind LC after a meal to avoid stomach upset.
• Nurokind LC should not be taken for a period longer than one month in the cases where there is no improvement in the symptoms.
• Nurokind LC may lower the levels of blood sugar. Thus you should carefully monitor your levels.
• Do not increase or reduce the dose prescribed by your doctor of Nurokind LC and do not stop taking the medications abruptly as it may cause some withdrawal signs.

Different Brands and Manufacturing Companies of the Drug

Nurokind LC is manufactured by Mankind Pharma Ltd. It is manufactured as either tablets or injection.

 Other brands that are manufactured by Mankind Pharma Ltd include:

• Nurokind D3 tablet contains Mecobalamin, Alpha-Lipoic Acid, Pyridoxine (VitaminB6), Folic Acid and Vitamin D3.
• Nurokind –Plus RF contains 1500 mcg Mecobalamin/Methylcobalamin, 100 mg Alpha-Lipoic Acid, 3 mg Pyridoxine (Vitamin B6) and 1.5 mg Folic Acid
• Nurokind-Gold Injection that contains 1500 mcg, 100 mg Niacinamide and 100 mg Vitamin B 6 (Pyridoxine)
• Nurokind-G tablet that contains 300 mg Gabapentin and 500 mcg Mecobalamin/Methylcobalamin
• Nurokind-G 100 tablet that contains 100 mg Gabapentin and 500 mcg Mecobalamin/Methylcobalamin
• Nurokind-G 1000 mg/500 MG injection that contains 1000 mg Cefaperazone and 500 mg Sulbactam
• Nurokind injection that contains 500 mcg Methylcobalamin/Mecobalamin
• Nurokind OD 1500 mcg injection that contains 1500 mcg Methylcobalamin/Mecobalamin
• Nurokind-Plus NF injection that contains 1500 mcg Methylcobalamin/Mecobalamin, 100 mg Niacinamide and 100 mg Pyridoxine (Vitamin B6)

Substitutes of the Drug

Alternatives of Nurokind LC that contains the same composition and strength include:

• Carnik LC tablet – Polaire Pharmaceuticals
• Carnimac Plus tablet – Macleods Pharmaceuticals Pvt Ltd
• Cynocal-LC tablet – Ozone Pharmaceuticals Ltd
• Trinerve LC tablet – Alkem Laboratories Ltd
• NE-C tablet – Cachet Pharmaceuticals Ltd
• Stamicar Forte Tablet – Panaca Biotec
• Hosit –L tablet – Emcure Pharmaceuticals Ltd
• Nurofer tablet- Khandelwal Laboratories Ltd

References

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