Vaccines

Vaccines child

Last Updated August 20th, 2021

Overview of vaccines

Numerous diseases can impact health and lifestyle at any point in time during an individual’s life. Few of them are contagious, few are fatal and few are resistible. Irrespective of the nature of the disease, the human body should have the capacity, more precisely the immune capacity to combat the pathogens or causative agents triggering these diseases. This necessitates adequate immunization in childhood through the injection of vaccines. But before that, a proper knowledge of the required vaccinations and possible reactions is necessary so as to determine the types of immunizations a child can sustain. Unfortunately, in many countries, the knowledge related to immunizations is lacking and this has resulted in 19.4 million immunocompromised infants worldwide in the year 2015.

 

What are vaccines?

VaccinesVaccines are medically defined as antigenic agents synthesized from the causative agent of a disease (or any other artificial substitute of the same) which are essential for building body immunity against several diseases. There are specific vaccines for different diseases and each of them has a significant role in building the body’s immune capacity. Vaccines are also known to be used to treat certain diseases (therapeutic vaccines). Vaccines are normally delivered in liquid form via injections, or via oral or intranasal paths. Vaccines are usually synthesized from whole microorganisms or specific components of microorganisms and provide protection against that particular pathogen (viral or bacterial) in future.

 

What are the properties of vaccines?

Two primary factors determine the disease-preventing ability of a vaccine. These are-

  • Effectiveness and durability of the administered vaccine
  • Vaccination coverage in a given population

Vaccines adultTwo important properties that determine the utility of vaccines are –

  • Vaccine effectiveness– It is defined as the performance of a particular vaccine under varying field conditions. Vaccine effectiveness strongly depends on the performance of vaccine delivery programs. It basically measures the ability of a vaccine to prevent the detrimental effects of a certain disease (such as hospitalization or death).
  • Vaccine efficacy– It is defined as the performance of a particular vaccine under specific study conditions (prospective approach). Vaccine efficacy measures the extent of prevention of a disease.

Apart from the ones discussed above, all vaccines should have the following essential properties-

  • Ability to provide long-lasting immunity
  • Ability to provide both humoral (extracellular) and cellular immunity
  • Should not trigger autoimmune effects or hypersensitivity
  • Should have a reasonable cost of production
  • Can be stored and delivered under normal environmental conditions
  • Should be safe to use

 

Types of immunizations

Immunizations are broadly classified into two categories. These are described below-

  • Active immunization: It is the type of immunization acquired via past occurrence of a particular disease. Individuals surviving the disease (caused by a specific pathogen) are less susceptible to the same disease in future. Active immunization involves the production of antibodies (humoral or cellular) in response to a specific antigen. Vaccines can induce active immunization by creating immunological memory (generate immune response similar to that evoked by a natural disease). It is usually long lasting in nature.
  • Passive immunization: It is the type of immunization in which antibodies are passed on to one person from another, such as from mother to fetus. This type of immunization is temporary in nature and cannot provide protection after the progressive degradation of antibodies. Transplacental immunization is the most common example of this type.

 

The working mechanism of vaccines

Vaccines childWhen vaccines are injected into the body in the form of inactivated or weakened pathogens, an immune response is triggered, which is similar to the body’s natural response to an infection.

The only difference is that in case of artificially injected pathogens, possibilities of occurrence of the disease is nil since the pathogens are in benign condition and do not have the capacity to cause infections.

The disease-causing pathogens are called “antigens” and the substances produced by the body in response to these antigens are called “antibodies”.

The antibodies combine with the antigens and destroy them through the mediation of the immune cells of the body (T lymphocytes). The artificially induced immune response creates immunological memory (both humoral and cellular) within the body and helps the body identify and destroy similar infectious pathogens in the future. In this way, diseases are prevented effectively.

 

Different types of vaccines

Vaccines are classified into different categories depending on the source of derivation and composition. These are discussed below-

Live attenuated vaccines

These vaccines are extracted from disease-causing bacteria or virus. These pathogens are attenuated and inactivated in the laboratory through repeated testing and culturing. Multiplication of the attenuated pathogens (in the form of vaccines) occurs within the body of the vaccinated person for a considerable period of time, which in turn triggers an immune response. These vaccines are usually provided in low dosage and do not cause disease within the body. In few rare cases, they might induce infections of very mild nature since these pathogens are almost benign in nature.

 What are the advantages? 

  • The injected microbes can help generate immunological memory similar to the one induced by natural disease.
  • Only a very small dosage is required since these microbes replicate within the body.
  • One time administration is enough for long-lasting immunity. Multiple booster doses are unnecessary.
  • Administration of whole microbes can cause protection against few other kinds of infections as well.
  • Few vaccines of this category can be delivered orally and can provide effective protection against the pathogen at the site of infection itself (Eg: vaccines for mucosal immunity and IgA synthesis). These oral vaccines are much cheaper.
  • These vaccines can help regulate epidemics.

What are the disadvantages?

  • In few rare cases, these supposedly benign vaccines may transform into virulent forms and cause severe infections.
  • Live attenuated vaccines cannot be provided to individuals having very weak immunity since they can cause serious illnesses and even death.
  • Optimum storage conditions are required since these microbes need to be in a condition to replicate after administration into the individual’s body.
  • Intervention by circulating antibodies in the body may impede the development of active immunity due to poor immune response.
  • These microbes are easily degradable and are extremely thermosensitive and photosensitive.

Inactivated vaccines

These vaccines are produced via bacterial and viral culturing in the laboratories and are then inactivated by heat or chemicals (mostly formalin). For synthesizing fractional vaccines, the inactivated microbes are further cultured and treated to extract only those components of the pathogen essential for vaccine preparation. A common example of this type is the polysaccharide capsule of Pneumococcus, In this case, chances of infection after administration of the vaccines are nil (even in an immunosuppressed individual) since the microbes are dead and cannot multiply within the body. A full dosage of the vaccine is administered at the same time. Two to three booster doses are required in this case for full protection against the disease. Examples of inactivated whole virus vaccines are- Influenza, Polio, Rabies and Hepatitis A. Examples of inactivated whole bacterial vaccines are- Pertussis, Typhoid, Cholera, and Plague.

 What are the advantages?

  • It is very safe to use and can be administered to immunosuppressed individuals and pregnant women
  • They are cheaper than attenuated vaccines
  • Optimum storage conditions are not required since the microbes are inactivated
  • They are not disturbed by circulating antibodies

What are the disadvantages?

  • A full dose of the vaccine has to be injected since the pathogens do not replicate within the body
  • A single dose only provides primary immunity. But for full immunity, multiple booster doses are needed
  • It is not very effective for generating cellular immunity
  • Few vaccines of this class can trigger adverse reactions after injection (Eg: encephalomyelitis induced by Bordetella pertussis)

Subunit vaccines 

Subunit vaccines are prepared from fractional components of the microorganism instead of the entire microbe. This is done in order to extract those antigens that provide protective immunity. Subunit vaccines are mainly made up of toxoids, subcellular components, and surface antigens. The performance of subunit vaccines is enhanced by administering them with adjuvants. They facilitate sustained immune stimulation.

 What are the advantages?

  • These vaccines can be safely administered to immunodeficient people
  • They normally do not produce side effects

What are the disadvantages?

  • These vaccines are less effective in terms of antigenicity. For example, peptide segments do not produce the same immune effect as that of the entire organism.
  • Some of the peptides are closely linked to the Human Leukocyte Antigen (HLA) and hence cannot provide complete immunity against all kinds of diseases.

Polysaccharide vaccines

These are a category of subunit vaccines made up of sugar molecule chains and are often found on the surface capsules of few bacteria. Immune response triggered by polysaccharide vaccines are usually T-cell independent. These vaccines are not very effective in immunodeficient people especially in infants (since they have immature immune systems). Performance of polysaccharide vaccines induced antibody is less than that induced by protein antigens because, in the former, very less IgG is produced. Examples of Polysaccharide vaccines are Pneumococcal, Meningococcal and Salmonella typhi.

Conjugate vaccines

These are primarily synthesized from capsulated bacteria and eliminate the problems related to polysaccharide vaccines. The conjugated bonds transform the immune response from T-cell independent to T-cell dependent. This enhances immunogenicity in infants. But one major disadvantage is that the extracted capsulated antigen acts as subunit vaccine and can enhance only humoral (extracellular) immunity. Also, multiple booster doses are required to induce complete immunity.

Recombinant vaccines

The vaccines produced by means of recombinant DNA technology or genetic engineering are called recombinant vaccines. The different means of preparation of this kind of vaccines are-

  • Use of engineered vector (Eg: Vaccinia virus)
  • Introducing mutation by deleting a portion of DNA
  • Reassortment of genomes of virulent and avirulent variants
  • Edible vaccines produced via introducing genetic coding for significant antigens in plants

What are the advantages?

  • These vaccines can be safely administered and are easy to store
  • Antigen segments having adverse effects can be safely removed from the main vaccine. Eg: Cholera toxin A can be safely eliminated from cholera vaccine

 What are the disadvantages?

  • Cost of production is high since the synthesizing process involves relocation, cloning, and expression of the antigen in the new vector
  • It generates adverse reactions in immunodeficient people

DNA vaccines

These types of vaccines are still in the research stage. In this case, the required antigens are located and cloned. The DNA is injected into the muscle cells of the vaccine recipient. They can also be introduced via the intranasal path. DNA vaccines provide both humoral and cellular immunity.

 What are the advantages? 

  • Transport and storage of DNA vaccines are very easy since the DNA molecules are very stable and are resistant to light and temperature
  • The DNA sequence can be changed anytime in the laboratory as per requirements
  • The injected DNA does not replicate and only the necessary proteins are encoded
  • Due to the absence of a protein component, no immune response is created against the inserted vaccine

What are the disadvantages?

  • Insertional mutagenesis may result from insertion of DNA into the host genome
  • Anti-DNA antibodies may be generated in response to introduced DNA

 

The dosage of common vaccines

Dosage recommendations of few common vaccines are listed below-

 

What are the adverse effects of vaccinations?

Infants having severe allergic reactions to vaccines should be immunized only after proper consultation with a pediatrician. In general, the following reactions are observed after immunization-

 

Benefits of vaccination

  • Vaccinations are administered to children to ensure that they do not end up with serious health conditions such as meningitis, measles etc.
  • Vaccinations help in ensuring that children don’t develop or acquire disabling or life-threatening malaises and infections.

Side effects of vaccinations

  • Fever
  • Headache
  • Fatigue
  • Joint or body pain
  • Shivering
  • Soreness or redness at the injection site.

 

Facts

  • A British scientist, Edward Jenner, developed the first smallpox vaccination in 1796.
  • 2-3 million deaths are prevented each year due to vaccines.
  • Vaccines are not always administered in the form of shots; they can be given orally as well.

Facts

  • In the late 18th century, King Charles IV of Spain wanted to spread the smallpox vaccination. He used 22 orphan boys who were vaccinated and their blood was used to make the vaccination

Facts

  • Since its introduction in 1998, the vaccination against bacterial meningitis has brought down the incidence rate of the disease by 99%.

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Dos and Don'ts

Dos
  • Get a flu vaccination every year to help prevent the flu.
  • Take the patient to the hospital in case there are any abnormal reactions posts the vaccination.
  • Maintain a healthy diet of whole-grains before getting a vaccination shot.
Don'ts
  • Vaccinate an infant if they are sick as their immune system would be weak. Doing so can make the pathogens enter the central nervous system and cause life-threatening damages.
  • Get your child vaccinated again with the same vaccines if your child had a reaction to it the first time. Doing so could lead to severe reactions

 

 

 

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How to scrub away stress and fatigue with an Epsom salt bath? Epsom salt is a popular home remedy for many skin ailments. Though there is a lack of scientific…
ANTI-MICROSOMAL-ANTIBODY-(AMA)
Anti-Microsomal Antibody AMA Test AMA or anti-microsomal antibody test is a blood test that measures the activity of AMA in the body…
Hysteroscopy_procedure
Hysteroscopy Hysteroscopy is a minimally invasive tool to help specialists view the uterus to diagnose and even treat several…
myelogram
Myelography Myelography is an important diagnostic tool that is used to investigate and identify abnormalities in the spine and…
anoscopy
Anoscopy Anoscopy is an invasive diagnostic procedure where a small device known as anoscope will be inserted in the…
cystatin C
Cystatin C Test Cystatin C is a specific single-chain protein that is found in body fluids and is a biomarker for…
What to eat, what not to eat in the South Beach Diet? The South Beach Diet is one among the most popular weight loss programs that have been the talk…
Is bronchitis contagious? And how to prevent this infection? It is acute bronchitis that is contagious which means you can contract it from another person or you…
arterial-blood-gas
Arterial Blood Gas Analysis Arterial blood gas analysis is a diagnostic procedure used to determine the volume of oxygen and carbon dioxide…
Tissue Transglutaminase Antibody (tTG) Test Transglutaminase is an enzyme present in our body and is involved in protein metabolism. A tTg test is…
blood ketone test
Blood Ketone (D3HB) Test The Blood Ketone Test measures and monitors the levels of ketone in the blood which is usually performed…
Diabetes blood test
Diabetic Profile The diabetic profile is a set of tests used for testing and monitoring the various kinds of Diabetes…
hidden benefits walking
9 benefits of walking we bet you didn’t know! Did you know walking can be the miracle pill for eternal youth? Everyone knows walking is good for…
Salt dangers
Sodium chloride: The wonders and dangers of the simple table salt Sodium chloride is a salt containing sodium and chlorine ions at a 1:1 ratio. It is edible and…
The right way to prepare Alfalfa sprouts at home Alfalfa or lusan ghas is not just a nutritious animal fodder. This flavonoid-rich herb has some amazing health…
Kava: Is it the healthy substitute for alcohol you have been waiting for? Native to the beautiful South Pacific islands, Kava is a famous beverage rooted in the local culture. It…
How to correctly perform nasal irrigation using a Neti Pot? Neti pot has been a part of Ayurveda since centuries. This ancient tool is extremely effective in treating…
11 unbelievable health benefits of thyme you didn’t know! Thyme is a herb that has been used in alternative medicine.It is a well known seasoning in the…
Barium-enema
Barium Enema Barium enema is also known as colon x-ray. Here, the patient is asked to consume small amount of…
hepatitis B envelope antigen
Hepatitis B Envelope Antigen (HBeAg) The HBeAg or hepatitis B envelope antigen test is a screening test used to diagnose the onset of…
L-theanine attention
L-Theanine: Better sleep, higher focus, and many other benefits Did you know that L-theanine found in green tea can make you sleep better and be focused at…
kefir bottle
Kefir: Top reasons why this probiotic drink should be consumed by you Yet another remarkable fermented food, kefir is a much healthier version of yogurt. These chewy white grains can…
Agave nectar: The bitter truth about this sweetener revealed Agave nectar is considered to be sweeter than the normal table sugar and even contains higher amounts of…
Bromelain: 11 reasons why you should start adding pineapple to your pizza! If you didn't love pineapples already, here are some of the top health benefits that bromelain can bring…
Find all the instant ways to get rid of blackheads Blackheads - Not only are they aesthetically unappealing but if left untreated these can cause bacterial overgrowth on…
Tattoo Aftercare: The best practices to follow once you get inked Planning getting permanently inked? Make sure you follow these critical tattoo aftercare techniques to avoid infectious agents attacking…
How accurate is the hair follicle drug test? Hair follicle drug test is one of the best ways to identify drug use in professional circles. But…
Inversion Therapy: The anti-gravity way of healing chronic back pain Inversion therapy involves suspending a person upside dow using different types of equipment. This works by taking the…
thyroid_scan
Thyroid Scan Thyroid scan is a diagnostic procedure that aims to view the thyroid gland and detect any growths or…
lp-pla2
LP-PLA2 Test The LP-PLA2 test is a test which is carried out to assess the levels of Lipoprotein-Associated Phospholipase A2…
complement c4 test
Anemia Profile Anemia Profile test (Basic) is a blood screening test that measures the levels of important components of the…
immunoglobulin M
Immunoglobulin M Test Immunoglobulin M is the largest and the first produced antibody which helps in the prevention or fighting of…
macadamia nuts in food
Proven health benefits and nutrition of macadamia nuts Know all about scientific, amazing health benefits of macadamia nuts, its nutrition, recipes, how to consume, price and…
macadamia nuts in food
Proven health benefits and nutrition of macadamia nuts Know all about scientific, amazing health benefits of macadamia nuts, its nutrition, recipes, how to consume, price and…
fitness routine fun
10 fantastic ways to make your fitness routine more fun! Are you too bored to exercise? Do you avoid gym cause it's too monotonous? Looking for fun and…
sleep deprivation
Don’t let your sleep deficit grow into memory loss or heart attack Why is sleep important for us? How could sleep deprivation harm you? We bet you didn't know about…
The complete “what to eat” guide for gluten intolerance Does eating breads and pastas often makes you nauseous? Gluten intolerance is a common reason why you might…
Pescatarian Diet 101: What are the inherent health advantages of this diet? People opt to become a pescatarian in order to enrich their bodies with the essential health benefits that…
Oxidative Stress: Understanding the most lethal phenomenon happening in your body right now Free radicals cause damage to the body, which is known as oxidation.  The amount of oxidation caused by…
Tamarind: The top health benefits of this staple Asian ingredient Did you know this sweet and sour pulpy fruit does more than just add a tangy flavor to…
SIBO Diet: The important dos and don’ts of this gut-healing diet A SIBO diet is a diet that works by eliminating certain sugars from your diet and adding fibers…
Internal bleeding brain
Beware: Ignoring these tell-tale signs of stroke could cost a life The signs and symptoms of a stroke differ depending on which part of the brain has been affected.…
Bubble Tea: Bubbling with nutrition or a hidden sugar mine? The tapioca pearls present in the tea looks like bubbles and hence the name bubble tea became popular.…
GGt test
GGT – Gamma-Glutamyl Transferase Test GGT or gammaglutamyl transferase test is a liver function test that is used to detect the extent of…
vdrl test syphilis
VDRL Test The VDRL test is a blood test that is used to diagnose sexually transmitted or venereal diseases, primarily…
Tachycardia heart
Cardiac Profile Cardiac profile is panel of blood tests performed to check cholesterol level and other heart disease markers to…