Anemia

Anaemia woman

Last Updated December 20th, 2021

Overview of Anemia 

The prevalence of anemia is the highest in India. At present nearly 50% of India’s population suffers from some form of anemia. A recent survey by the National Institute of Health has revealed that nearly 74% of the pregnant women in India suffer from the disease.

On a regular basis, we come across people who are apparently strong and healthy but are medically not fit. These people suffer from multiple deficiencies like pale skin, breathlessness, muscle cramps, fatigue, frequent palpitation, and sluggishness. These are inevitable symptoms of a hemoglobin deficiency disease namely “anemia”. Due to less severity of the disease at a primary stage, people usually neglect diagnosis and treatment. But when the disease persists for a prolonged period of time, the damages caused to the body are irreparable. According to the records of Center for Disease Control and Prevention (CDC), nearly 48 % of infants, 25 % of school children and 42% of pregnant women are victims of this disease worldwide.

What is anemia?

Anemia is the pathological condition in which the red blood cell (RBC) count drops in blood. This, in turn, leads to hemoglobin deficiency and subsequent lack of oxygen supply to blood.

What causes anemia?

Anaemia nailsThere are numerous etiological factors behind anemia. Listed below are few clinical conditions that predispose the body to the disease –

  • Iron deficiency: Shortage of iron in the body occurs mainly due to lack of iron (Fe) containing nutrients in the regular diet. Presence of permanent ulcers or cancerous cells within the body is a prime contributor behind Fe deficiency. Individuals suffering from Celiac disease have damaged intestinal walls (inner lining of the small intestine) which lead to acute “iron absorption” failure by the small intestine. This causes a deficiency of iron in the body. In women, monthly loss of blood due to menstruation causes iron deficiency at puberty. Shortage of iron in the body impedes hemoglobin formation by the bone marrow, which leads to a reduced percentage of Red Blood Cells (RBC) in blood.
  • Vitamin B12 deficiency: Vitamin B12 is essential for the formation of Red Blood Cells. Deficiency of either Vitamin B12 or Folate compounds in regular diet can equally contribute towards anaemic symptoms. 

What are the major warning signs ?

Anaemic symptoms are often overlooked due to lack of knowledge or attention. The following symptoms are critical indicators of the disease at different stages-

  • The skin turns pale or a sick yellow
  • Frequent muscle cramps
  • Breathlessness after slight physical activities
  • Extreme exhaustion
  • Profuse sweating and increased thirst
  • Frequent headaches
  • Lethargy throughout the day
  • Irregular heart rate (palpitation)
  • Frequent mood swings and irritability
  • Nausea

What are the different categories?

Anaemia womanAlthough iron-deficiency induced anaemia is the most common form, there are three other types of anaemia people need to be aware of. All categories have been elaborated below:

Iron deficiency Anaemia: During certain clinical conditions the body needs more iron than usual to synthesize hemoglobin that supports the RBC. On various occasions, low intake of iron in daily food items, excessive drainage of iron from the body due to menstruation or pregnancy causes an increased demand for iron in the body. When this demand is not met, acute iron deficiency occurs resulting in anemic conditions.

Vulnerable groups

    • Women in their adolescence or during pregnancy period
    • Children lacking proper diet
    • People affected with Crohn’s symptoms, Celiac disease or renal failure
  • Patients having internal injury and hemorrhage

Pernicious Anemia: This disease occurs due to the deficiency of either Vitamin B12 or Folic acid derivatives in the body. This condition arises when the body lacks a particular protein called Intrinsic Factor (IF) which helps to extract Vitamin B12 from the nutrients in the daily diet. 

Vulnerable group: People lacking meat, egg and dairy products in their regular diet

Aplastic Anaemia: This is a relatively critical form of anemia which encompasses three distinct conditions –

    • A drastic drop in the count of RBC (anaemia)
    • Reduced platelet count (thrombocytopenia)
    • Drop in White Blood Cells count(Leukopenia)
  • These three conditions are collectively called pancytopenia.

Vulnerable group: Cancer patients undergoing chemotherapy or radiotherapy

Haemolytic Anemia: This is the rarest form of the disease where normal RBCs die much before their usual lifespan (120 days), but the body cannot instantly cover up for those RBCs by forming new RBCs. Hemolytic Anemia is further subdivided into two types: Acquired Hemolytic Anaemia and Inherited Hemolytic Anaemia.

Vulnerable Groups: Any person can develop this disease depending on their environment and genetic pattern.

What are the long-term systemic effects?

Long-term effects of Anemia, especially the one caused by iron deficiency is perceived at a much later stage and are usually irreversible in nature. Following are the long-term and permanent effects experienced by chronic anemic patients:

  • Cognitive disorders in the form of disturbed behavioral and physical growth patterns are observed in growing children
  • A permanently damaged immune system is evident in all age groups exposed to anaemia for a considerable period of time
  • Deterioration in muscle activities takes place which eventually leads to decreased productivity
  • Prenatal risks are increased manifold
  • Infant mortality rates might be escalated

Is there any hereditary factor?

Flemming et al of the Harvard Medical School research team has discovered a particular mutated gene called TMPRSS6 that triggers iron deficiency causing different degrees of anemia. Again, deficiency of TMPRSS6 protein spurs the formation of excess hepcidin hormone that prevents effective iron absorption by the intestine. Hence it is clear that gene has a distinct role in this case.

Treatment and prevention

Anaemia foodTreatment options for anemia include:

  • Iron tablets and supplements which can be taken at empty stomach (if they don’t cause any digestive disorders). These are generally taken over a period of several months.
  • Improve dietary habits and include iron and folate-rich foods in your diet such as spinach, kale, broccoli, dry fruits and nuts, and liver.
  • Consume citrus fruits and juices that contain vitamin C, along with iron supplements to aid better iron absorption.

Preventing anemia involves:

  • Consuming an iron and folate-rich diet especially for pregnant women.
  • Breastfeeding women should also keep their hemoglobin level on a check. Infants should be breastfed properly and/or given iron-fortified milk formula.
  • Menstruating women and frequent blood donors should also monitor their hemoglobin level and keep consuming iron-rich foods.

Facts

  • Iron is not the only essential nutrient whose deficiency can cause anemia. Vitamin B12 deficiency or folate deficiency can also result in anemia.
  • Due to a lack of EPO of erythropoietin, people on dialysis often tend to become anemic. EPO is produced by healthy kidneys.

Facts

  • Young women are at the highest risk of getting anemia. This is majorly because of monthly menstrual cycles. People who are frequent blood donors are also at risk.
  • In a healthy human body, RBCs live for up to 120 days after which they are systematically replaced by bone marrow, spleen, and the liver.

Facts

  • Infants who are born pre-term and/or have low birth weight also have reduced RBC count. C-section babies are also anemic during the neonatal stage.

Related Conditions

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Dos and Don'ts

Dos
  • Consume a diet rich in iron and vitamin B12. These are abundantly available in spinach, liver, legumes, shellfish, and quinoa.
  • Get an adequate amount of vitamin C from your diet as well. Vitamin C aids in iron absorption.
  • Maintain proper hygiene and sanitation to protect yourself from infections as anemia directly reduces one’s immunity.
Don'ts
  • Consume tea, coffee, or aerated cola drinks with meals as these tend to decrease iron absorption in the body.
  • Eat calcium-rich foods/ calcium supplements along with iron supplements as these tend to reduce iron absorption.
  • Worry if your stools appear slightly darker when taking iron supplements. But do consult doctor if constipation occurs and persists.

 

 

 

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Myelography Myelography is an important diagnostic tool that is used to investigate and identify abnormalities in the spine and…
HSV-1_IGG
Herpes Simplex Virus I (HSV)-IgG Test Herpes simplex virus I(HSV)-IgG is an Immunoglobulin protein that acts as an antibody & stays in the blood…
Thyroid disorders
Thyroid Profile Thyroid profile is a panel of blood tests performed to check if an individual is suffering from any…
AUTOIMMUNE HEPATITIS liver
Hepatitis Profile A hepatitis profile or a hepatitis panel is a blood test that checks for markers of hepatitis infection…
Hepatitis A virus infected liver
Hepatitis A Virus (HAV) Total Blood test to look for IgM antibodies to know if you are infected with Hepatitis A virus (HAV),…
carrageenan seaweed
Carrageenan: How a simple seaweed extract could better your gut health & immunity Eat more ice cream to prevent cold and flu? –With carrageenan you get one simple seaweed extract that…
dance health benefits
5 unbelievable effects of dance on your overall health! You enjoy dancing, but did you know what else it does to your body? Dancing is not only…
Jack in the box fast food
Jack In the Box : The perils of surging fast food culture in the USA Jack in the Box - How a culture of fast-food can clog your arteries, weaken your heart, fatten…
Kava: Is it the healthy substitute for alcohol you have been waiting for? Native to the beautiful South Pacific islands, Kava is a famous beverage rooted in the local culture. It…
How seitan proved to be a blessing in disguise for vegans worldwide Can only meat-eaters enjoy delicious juicy steaks and burgers? With seitan, the best meat substitute available today,even vegans…
Appendix pain: Recent findings on this not-so vestigial organ The exact function of the appendix is still not clear. Some consider it as an organ that once…
Surgery or home-remedy; what is the right way to treat a burn The treatment of a burn injury depends on its severity. You can save a life by offering the…
liver cleanse detox
14 go-to foods that are best for a complete natural liver detox Liver cleanse can be achieved by just choosing or avoiding certain types of food. Liver itself is a detoxifying…
Chest X-Ray A chest x-ray is a diagnostic test that uses x-rays to visualize the structures inside your chest. It…
Strep throat pain
Anti-Streptolysin-O Test The ASO or Anti-Streptolysin-O is a blood test designed to check for the presence of streptococcus bacterial infection…
phenytoin test
Phenytoin test Phenytoin is a drug that is administered mainly to epilepsy patients. The phenytoin blood test measures the level…
AHBC Igm
Anti-Hepatitis B Core Antigen (AHBc) IgM Anti-hepatitis B core antigen (AHBC) IgM is an investigative procedure to detect the presence of IgM antibodies in…
ureteroscopy
Ureteroscopy Ureteroscopy is the diagnostic procedure which is used for the detection of the kidney stones in addition to…
Unbelievable health benefits of gooseberries (and a few tasty recipes) Gooseberries are antioxidant-rich tasty fruits that can be easily added in daily diet to improve overall health and…
Squid-ink-spaghetti
Squid Ink: A unique food coloring and flavoring agent Want to add a unique black color to your pasta, noodles and ice-creams? How can you use squid…
Squid-ink-spaghetti
Squid Ink: A unique food coloring and flavoring agent Want to add a unique black color to your pasta, noodles and ice-creams? How can you use squid…
Squid-ink-spaghetti
Squid Ink: A unique food coloring and flavoring agent Want to add a unique black color to your pasta, noodles and ice-creams? How can you use squid…
piles fissure fistula
Allopathy vs homeopathy vs ayurveda treatment for piles, fissures, and fistula Read to know the best form of treatment among allopathy, homeopathy,or ayurveda for piles, fissures, and fistula
cancer facts
8 hard-hitting truths no one tells you about cancer Did you know that 1.5 million new cases of cancer are reported every year? Can second-hand smoking kill…