Voglibose

Therapeutic Indications for Voglibose

Voglibose is used in the long-term treatment of patients with impaired glucose tolerance.  With the trade name of Voglib, this drug effectively helps in the management of Type 2 Diabetes Mellitus by lowering blood glucose level in patients.   Voglibose is an orally active alpha glucosidase inhibitor that particularly assists in control of postprandialhyperglycaemia (PPHG).

Specifically, healthcare specialists resort to Voglibose in Diabetes management for lowering PPHG, whena combination of OHAs or insulin preparations along with diet and/or exercise has not producedsignificant improvement in control of blood sugar.

Voglibose is manufactured as tablets for oral intake with strengths of 0.2 mg and 0.3 mg. This medicine is used in isolation or in combination with other drugs to achieve the desired effect.

Do I need a prescription?

Voglibose can be purchased from a pharmacy or drug store only with a prescription from a qualified medical practitioner.

Dosage

Dialectologists individualize the dosage of Voglibose based on the manner of response to the drug as well as tolerance.

• The dosage of Voglibose for adults is fixed at 0.2 mg administered orally three times daily.
• Take Voglibose just before each meal. The same dosage applies for patientswith steroid induced diabetesand non-diabetic hyperinsulinaemia.
• Take care not to exceed the maximum recommended dose of 0.6 mg.
• Higher dose of Voglibose 0.3 mg is recommended three times daily before each meal only if the response to patients with 0.2mg dose has proved ineffective.
• When Doctors prescribe Voglibose, they also advice strict changes to diet and lifestyle.
• Dose titration is effected only if patients do not respond as expected to the initial dose of Voglibose.
• For Insulin Dependent Diabetes Mellitus IDDM,doctors prescribe a dose of 0.2 to 0.3 mg of Voglibose prior to meals in combination with insulin administration.
• Dosage for victims of glycogen storage disease is fixed at 0.1mg Voglibose along with lunch and dinner. This has the capability of lowering the incidence of hypoglycaemic episodes and is as effective as compared to patients who are not on any medication.
• Store the drug in a safe place away from children and pets.
• Voglibose should ideally be stored in adry place  at temperatures below 30degrees Celsius.

 Chemical Composition

Voglibose tablet contains Voglibose, Mannitol 200, Collidal Silicon dioxide, flavorant and lubricant.

Mechanism of Action

Voglibose achieve anti-hypoglycaemic effect in the following manner:

The alpha glycosidase hydrolyses enzymes, oligosaccharides and disaccharides to glucose and other monosaccharides in the small intestine.

So effectively, Voglibosehelps in delaying the digestion and absorption of dietary polysaccharides by reversible control of carbohydrate digestive enzymes, for instance, zomaltase, maltose, and sucrose which impacts post prandial hyperglycaemia positively.

Voglibose also assists mobilisotary alpha endogenous glycogen-like peptide 1 (GLP-1), which has an inhibitory action on glycogen, thus lowering fasting glucose levels.

Voglibose also causes the improved release of insulinotrupic hormone, GLP-1, which results in better insulin sensitivity and secretion.

Contraindications

Voglibose can trigger adverse reactions in the presence of medical conditions/diseases. It can also interact with other medicines, vitamins and supplements, therefore it is imperative to disclose your complete medical history, drugs you take or are allergic with your medical specialist. Some of the contraindications of this drug are as follows:

Allergy

Do not take Voglibose if you are allergic to any of the ingredients of the medicine.

Disease/Medical Condition Interactions

Digestive Disorders and or/Intestinal obstruction

Patients that suffer any form of intestinal problems for instance chronic ulcers, Inflammatory Bowel Disease should not take Voglibose. Those in the grips of chronic digestivedisordersshouldalso avoid this medicine.

Diabetic Ketoacidosis

Specialists under such conditions adjust the dosage of Voglibose and monitor. In few cases of Diabetic ketoacidosis, doctors recommend dosage adjustment. Insevere cases of acidosis, avoidVoglibose completely.

Substance

Alcohol

It is yet unclear about the possible interaction this drug can have with alcohol. If you are on Voglibose, consult your specialist before alcohol consumption.

Food Interaction

The possibility of interaction of Voglibose with certain types of food is still unclear. Report anyobservation to the healthcare specialist for further action.

Interaction with Medicine

Take Voglibosewith extreme caution if you are already on other types of medication, to reduce blood glucose level,for instance insulin. In such cases, close monitoring of blood sugar is necessary.

Caution for special population

Pregnancy

Expectant women should not take Voglibose unless the benefit of taking this drug outweighs the risks significantly. Discuss with your healthcare specialist about the risks of taking this drug during pregnancy. It is also possible that your specialist will prescribe an alternative medicine after evaluating your conditionwith fewer side effects.

Breast-feeding

Lactating mothers should tread with caution in the use of Voglibose.  The drug is conveyed through breast milk to the infant; therefore discuss the risks of taking this drug with your specialist. If absolutely needed, your specialist may prescribe an alternative medicine.

Paediatric use

Doctors do not prescribe Voglibose for paediatric use.

Liver impairment

Victims of impaired liver should ascertain the risks of taking Voglibose. Doctors are likely toadjust the dosage of this drug if it is absolutely needed and may monitor the patient during the course of treatment.

Kidney impairment

Use this medicine with caution among patients with kidney impairment. Dose adjustment and safety monitoring in such cases is imperative.

Insulin-dependent Diabetes Mellitus (IDDM)

Voglibose is not to be adopted as the sole therapy in victims of Insulin-dependent diabetes mellitus (IDDM).

Patients that have a history of abdominal laparotomy, stenosis orRoemheld’s syndrome should use this drug with extreme caution.

Side Effects

Intake of Voglibose can cause both major and minor side effects. The minor side effects settle down in time, the cardinal rule is to consult your healthcare specialist if side effects persist. Deal with severe side effects immediately.

Some of the side effects are listed below:

• Pneumatosis Intestinalis
• Flatulence
• Dizziness
• Fatigue
• Nausea
• Vomiting
• Diarrhea
• Abnormal liver function

What to do if I skip a dose

It is good to take the missed dose as soon as it crosses your mind. However, if it is too close to the next scheduled dose, it is wise to skip it and just stick to the next dosage that is due.  Never compensate for the skipped dose by taking a double dose.

Overdose

Overdose of Voglibose is dangerous as it affects blood sugar levels. Contact your medical specialist immediately.

Generic and brand names of Voglibose

Generic:Voglibose

Brand: Voglib

Different manufacturing companies of Voglibose

Substitutes for Voglibose

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