Plague


Last Updated December 20th, 2021

What is the plague?

Plague, also referred to as the black plague, is a zoonotic disease that is caused by Yersinia pesti, a type of bacteria. This disease affects humans as well as other animals. Rodent fleas – which are found in rats

mice, squirrels, rabbits, prairie dogs, chipmunks, voles – are normally the vectors that transmit this disease from animals to humans. However, humans also contract this disease when handling an infected animal.

Plague is one of the oldest diseases known to man. During the middle ages in Europe, the plague was responsible for the deaths of millions of people. Today, plague can be treated effectively by antibiotics, although it can still be life-threatening in the absence of prompt treatment.  Many cases of plague are still prevalent in parts of Asia and Africa.

A brief history

The first recorded plague pandemic was known as the Justinian Plague. It happened in the 6th century and was named after Byzantine emperor Justinian I. It killed over 25 million people over a period of two hundred years (541 C.E to 741 C.E)

The second pandemic – the infamous “Black Death” or the Great Plague – originated in China in 1334 C.E. It then spread to Constantinople (modern Istanbul) before reaching Europe, where it killed 60% of the population.

The third pandemic – also known as the Modern Plague – again in China in the 1860s and appeared in Hong Kong by 1894. It then spread to port cities around the world by rats on ships. It caused approximately 10 million deaths. However, during the third pandemic, scientists were also to determine that plague was caused by a bacterium and was transmitted via flea bites.

After antibiotics were introduced in the 1940s, the mortality rates of plague dramatically went down. Today, less than 200 people die from the plague, which is still prevalent in rural areas of Africa.

Types of plagues

They are three types of plagues

Bubonic plague

This is the most common type that affects a person’s lymphatic system. It gets in name owing to the fact that it causes buboes, swollen and painful lymph nodes under the arms, in the neck, or in the groin. This type is usually transmitted when a person is bitten by an infected rodent or a flea. In some rare cases, a person may get this disease when he/she comes in contact with an infected person. The bacteria spread to other parts of the body if left untreated.

The most common form of plague is the bubonic plague. It’s usually contracted when an infected rodent or flea bites you. In very rare cases, you can get the bacteria from material that has come into contact with an infected person.

Septicemic plague

This type is more dangerous compared to the bubonic plague. Septicemic plague happens when the bacteria move into a person’s bloodstream. The most common symptoms include

  • Bleeding from mouth, nose, bottom, under the skin
  • Blackened skin
  • Stomach ache
  • Diarrhea
  • Vomiting

Pneumonic plague

This is the rarest type and is caused when the bacteria reach a person’s lungs. This type is very contagious as it is spread when the infected person coughs or sneezes. Some symptoms of this disease include

  • Persistent coughing
  • Breathing problems
  • Nausea and vomiting

Causes

Plague is more prevalent in areas with overcrowding, poor sanitation and large populations of rodents (especially rats). It

Yersinia pesti can be transmitted to humans in the following ways

Flea bites

This disease is usually transmitted to people when they are bitten by an infected flea. This happens when a plague outbreak among animals results in the death of many rodents (which are the fleas’ primary host). This prompts the fleas to look at alternate sources of blood. A person or an animal that visits places, where rodents have recently died, are at a high risk of being bitten and infected by fleas.

Contact with contaminated meat

If a person comes in contact with a plague-infected animal, he/she may get the plague. This usually happens when a person comes in direct with an infected animal’s tissue or fluids. For example, a butcher skinning an infected animal without using proper precautions could become infected with the plague.

Contact with infected animals

Cats are very susceptible to plague due to their tendency to hunt and consume rodents. An infected cat can transmit plague via to their owners via droplets. In USA, cats are responsible for many cases of plagues

Droplet infection

This happens when a person breathes in air contaminated with cough or sneeze droplets from an infected person. This, however, only happens when a person comes in direct contact with an infected person. This type of transmission is usually rare in developed countries but is still prevalent in developing countries.

Symptoms

After an incubation period of 2-6 days, most infected people develop flu-like symptoms. The other symptoms of plague are varied depending on the type of infection.

Bubonic plague

Bubonic plague is always characterized by painful, swollen lymph glands, called buboes, which appear in the groin, armpits, neck. Other symptoms may include

  • Fever and chills
  • Headache
  • Muscle pain
  • General weakness
  • Seizures

Septicemic plague

The symptom of septicemic plague usually starts after the onset of the Bubonic plague. Sometimes, the septicemic plague may be fatal even before the symptoms appear. These symptoms can include

  • Abdominal pain
  • Diarrhea
  • Nausea and vomiting
  • Fever and chills
  • Extreme weakness
  • Bleeding (blood may not be able to clot)
  • Shock
  • Blackening of skin

Pneumonic plague symptoms

Pneumonic plague symptoms usually appear very quickly, sometimes even a day after infection. Some of the symptoms may include

  • Trouble breathing
  • Chest pain
  • Cough
  • Fever
  • Headache
  • Overall weakness
  • Blood in sputum

Complications

Plague may cause the following complications

Death: Although the mortality rate of plague has drastically reduced since the development of antibiotics, people who do not receive prompt medical treatment die.

Gangrene: Gangrene is a condition where tissues of the body die due to lack of blood supply. This often happens in the hands and feet. Plague causes blood clots in the tiny blood vessels of the hands and feet. This results in tissue blackening. Tissues affected with gangrene generally need to be amputated.

Meningitis: This is a serious condition which is characterized by the inflammation of the membranes (meninges) surrounding your brain and spinal cord. Although rare, plague causes meningitis.

Diagnosis

Plague can be diagnosed in the following ways

  • Blood test: The doctor will take a blood sample from the suspected patient and analyze it for the presence of Yersinia pesti.
  • Analysis of lymph node fluids: The doctor may also take insert a needle into one of the infected patient’s lymph nodes and analyze it to determine the presence of Yersinia pesti.
  • Bronchoscopy: This is a procedure that lets doctors look at the patient’s lungs and air passages for any signs of pneumonic plague infection.

Treatment

Plague is a life-threatening disease that requires immediate medical care. With no proper treatment, bubonic plague can turn into septicemic plague and pneumonic plague very quickly. A person can die within 24 hours after the appearance of the first symptom. Treatment includes

Antibiotics: Plague is primarily treated by the administration of strong antibiotics such as gentamicin or ciprofloxacin.  With antibiotics, most people get better within a week or two. However, the course needs to be continued for several weeks even after the symptoms resolve.

Quarantine: People with plague (especially the pneumonic plague) should be isolated from other patients.

Prevention

Plague can be prevented by following these measures.

Controlling the rodent population

Rodents are the main vectors of fleas, which may carry the plague bacteria. You can use poisons or traps but doing so may only prove to be a temporary solution. If you want to get rid of a rodent problem once and for all, you’ll need to seal all potential entry points. You should also always dispose waste properly so rodents are not attracted.

Taking the right measures while handling the meat of potentially infected animals

You should always wear gloves while skinning an animal, especially rabbits or some small game. You may contract plague if your bare skin comes in contact with tissues or blood.

Using insect repellents while going camping or hiking

You should always apply insect repellents on the exposed areas of your skin while doing an outdoor activity like hiking, trekking or camping.

Treating your pets for fleas

As fleas are the vectors of plague, you should treat your pets for fleas as soon as possible. If your pet has the habit of roaming freely, it is more susceptible to getting infected fleas. Such pets should not be allowed to sleep on your bed or couch.

Do dead bodies spread plague?

The body of a recently deceased plague victim can infect people who come in close contact with the body. Hence, care should be taken by the people who prepare the body for burial or cremation. The bacterium will mostly be concentrated in the body fluids.

 

Dos and Don'ts

Dos
  • Always take your full antibiotics course as recommended by the doctor. Do not stop even after the symptoms get better.
  • Always close your mouth or nose while sneezing or coughing to reduce the risk of spreading it to others.
  • Gets pets regularly checked for fleas
Don'ts
  • Panic as the plague is full treatable disease.
  • Go to plague-infested areas without taking proper precautionary measures.
  • Let pets sleep with you if they have fleas

 

 

 

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Herpes Simplex Virus (HSV)-IgM Test The HSV-IgM class antibody is produced by the body a few days after an initial HSV infection and…
Hymenoplasty
Hymenoplasty Read on to find out all about hymenoplasty, the procedure, post-surgery care, the risks, and the benefits.
Hepatitis A virus infected liver
Hepatitis A Virus (HAV) Total Blood test to look for IgM antibodies to know if you are infected with Hepatitis A virus (HAV),…
Oxalates: How healthy greens can sometimes be bad news for your kidneys Oxalates are compounds present in a majority of healthy foods. However, at times an overconsumption of these could…
How can berberine supplements help you live longer and healthier? Berberine is a turmeric look-alike herbal extract that is credited with numerous health benefits ranging from diabetes cure…
sleep deprivation
Don’t let your sleep deficit grow into memory loss or heart attack Why is sleep important for us? How could sleep deprivation harm you? We bet you didn't know about…
Exercises or diet? Find out the healthiest way to gain weight Tired of being called skinny all the time? Looking for healthy ways to beef up? Why not try…
amylase test
Amylase Test Amylase test is done by checking the level of this protein in the blood sample and also in…
woman with abdominal pain holding ovulation calendar
Ovulation – facts to know about ovulation Learn how and when ovulation occurs, demystify common misconceptions, identify symptoms, methods of detection and right period for…
folate test
Folate test The Folate test measures and monitors the levels of folic acid in the blood. This test is also…
Okra: How can this nutrient-dense vegetable help you fight diabetes? Okra is a food which is rich in nutrients and minerals which are extremely essential for a healthy…
Barium-enema
Barium Enema Barium enema is also known as colon x-ray. Here, the patient is asked to consume small amount of…
shiitake mushrooms healthy
What are Shiitake Mushrooms and why should you eat them? Shiitake Mushrooms are well known for their smoky and robust taste. However, did you know they are replete…
The Cabbage Soup Diet: The healthiest way to instant weight loss Cabbage soup diet rapid weight loss diet for those who want to shed those extra pounds in less…
apolipoprotein a1 test
Apolipoprotein -A1 (APO-A1) Test Apolipoprotein A-I (Apo-A1) constitutes 70% of protein content in high-density lipoprotein (HDL) and helps in lipid metabolism.
CEA_test
Carcinoembryonic antigen (CEA) test CEA or carcinoembryonic test detects the presence of CEA antigen in your blood mainly & determines the effectiveness…
colposcopy
Colposcopy Colposcopy is a simple, quick and non- invasive diagnostic tool to look closely inside the vulva, vagina, and…
Vitamin K2: 8 reasons why you need this bone-building & cancer-fighting nutrient Vitamin K2 is claimed to be essential for your bone health, for reducing the risk of cancer, and…
blood elements analysis
Blood Element Analysis Test A blood element analysis is a blood test performed to measure the level of toxic elements such as…
How can Kegels help you overcome weak pelvic muscles & incontinence? Kegel exercises are pelvic floor strengthening exercises that can help you overcome incontinence issues that rise out of…
Optavia diet
The features of an Optavia diet The Optavia diet endorses pre-packaged meals and snacks called "fuelings" that are tasty, low in calorie, and incorporates…

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