Addison’s Disease

ADDISON'S DISEASE skin

Last Updated December 20th, 2021

Introduction

The adrenal glands are a pair of glands located on top of the kidneys, just below the diaphragm. These are endocrine glands that are responsible for producing a variety of hormones such as adrenaline, cortisol, corticosterone, aldosterone and even certain male hormones collectively called androgens. Broadly, each such gland is divided into two areas, both of which produce hormones. These two parts are the outer adrenal cortex and the inner medulla. There can be quite a few different disorders of the adrenal glands, ranging from tumors and congenital adrenal hyperplasia to Cushing’s disease and Addison’s disease.

 

What Is Addison’s Disease?

Addison's disease joint painAddison’s disease is an endocrine disorder that affects the adrenal glands. This disorder is also known by the name ‘primary adrenocortical insufficiency’. It arises when the glands are damaged or, for various reasons, unable to produce as much cortisol as the body needs. In patients suffering from Addison’s disease, the adrenal glands may also produce too little aldosterone.

The endocrine system and the production of hormones are tightly regulated through a process known as homeostasis. The production of hormones rises and falls through the day in response to changes in the internal and external environments. When the body experiences stress, the anterior pituitary gland in the brain produces adrenocorticotropic hormone whose function is to stimulate the adrenal glands to secrete more cortisol.

Cortisol is called the ‘stress hormone’. It regulates metabolism and inflammatory response. It maintains the levels of blood sugars, electrolytes, and water in the body. Hence, a shortage of cortisol adversely impacts all of these important physiological processes and parameters, leaving the body incapable of adapting to adverse conditions such as dehydration or an abnormally low level of blood glucose.

 

What Causes This Disorder?

There can be a variety of causes for Addison’s disease, ranging from surgical trauma to infectious disease. One of the main causes of Addison’s disease is autoimmune activity. The function of the immune system is to protect the body from foreign matter and pathogens such as bacteria, viruses, parasites, and fungi. This helps to prevent infectious disease, keeping the body healthy and functioning normally. Sometimes, though, and for reasons not yet well understood, the immune systems end up mistaking the body’s own cells as health threats. The immune system attacks these healthy cells, thus giving rise to a variety of problems. This is known as an autoimmune disorder. The list below sets out some possible causes for Addison’s disease:

  • Being female is associated with a higher likelihood of developing this condition.
  • Tuberculosis is one of the common causes of Addison’s disease.
  • A variety of other infections.
  • Trauma to the gland/s.
  • Bleeding or hemorrhage into the adrenal glands.
  • Disorder of the pituitary gland.
  • Autoimmune disorder.
  • Having a close family member who suffers from an autoimmune disorder is a risk factor.
  • Treatment for Cushing’s syndrome.
  • Taking blood thinners for extended periods of time.
  • Amyloidosis.
  • Cancer cells from other organs or tissues spreading to the adrenal glands.
  • Adrenoleukodystrophy.

 

What Are The Indications Of Addison’s Disease?

ADDISON'S DISEASE skinSymptoms of Addison’s disease tend to manifest under conditions of stress, infection, dehydration or trauma. It is under such conditions that the body most needs cortisol. Hence, it is on such occasions that the effects of the hormonal deficit are felt most acutely.

The general symptoms are as follows:

  • Brain fog or confusion.
  • Nausea.
  • Diarrhoea.
  • Irritability.
  • Loss of appetite.
  • Impaired thyroid function.
  • Weakness.
  • Hyperpigmentation of the skin.
  • Poor sleep.
  • Chills.
  • Vomiting.
  • Low blood pressure.
  • Low blood sugar.
  • Fainting.
  • Weight loss for no other apparent reason.
  • Depression.
  • Sexual dysfunction in female patients.

 

What Are Some Possible Complications?

Patients suffering from untreated Addison’s disease are at risk of developing what is known as an Addisonian crisis. This is also called acute adrenal crisis and should be treated as a serious medical emergency. The patient could suffer from hypovolemic shock, seizure or coma and they could even die.

 

How Is It Diagnosed And Treated?

ADDISON'S DISEASE kidneysThe following procedures form part of the standard diagnostic protocol that can help identify Addison’s disease:

  • Physical examination.
  • Medical history. Particularly any recent history of infections like tuberculosis or autoimmune disorders.
  • Blood tests to determine the levels of hormones and electrolytes.
  • Adrenocorticotropic hormone stimulation test.
  • Diagnostic imaging to assess the condition of the glands.

Treatment for Addison’s disease mainly involves taking medications that provide your body with the hormone that it is unable to produce on its own. Patients suffering from the Addisonian crisis are immediately administered an injection of hydrocortisone that helps to alleviate symptoms and return the body to a normal state.

Prevention is mainly by treating the underlying conditions and taking care of the risk factors such as fungal infections, TB etc.

 

Facts

  • The prevalence of Addison’s disease is found to be around 40 to 60 individuals in the population of 1 million.
  • Addison’s disease affects males lesser when compared to females.

Facts

  • Around 8,400 people in the United Kingdom have Addison’s disease.
  • The destruction of 90% (at least) of the adrenal cortex is found in cases of Addison’s disease.
  • Both the adrenal glands weigh only 8-10 grams together.

Facts

  • Around 60-70% of cases of autoimmune adrenalitis get Addison’s disease.
  • Infections such as tuberculosis and fungal infections increase the risk of Addison’s disease.

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Dos and Don'ts

Dos
  • Always carry a medical alert card and a bracelet for emergencies and accidents. This will inform the emergency medical staff about your condition and the treatment that has to be given in the event you are incapacitated.
  • Keep extra medication readily available. A small supply of medications should be kept in the workplace, travel bags, in your car, etc. so that you don’t miss a dose even if you forget it before leaving home.
  • Get an injectable form of corticosteroids prescribed by your doctor along with a needle and syringe. This can be used in case of emergencies.
Don'ts
  • Ignore symptoms such as muscle weakness, weight loss, fatigue that worsens with time, low blood pressure etc.
  • Miss your follow-up visits. This will help the doctor to evaluate the adequacy of the doses of replacement hormones. Minor adjustments might be required in the dosage in case there are persistent problems.

 

 

 

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Jack In the Box : The perils of surging fast food culture in the USA Jack in the Box - How a culture of fast-food can clog your arteries, weaken your heart, fatten…
Moringa drink
Moringa: This could be the most nutrient-dense food known to us! Moringa is a lush green tree brimming with over 90 essential nutrients required for a healthy mind and…
Kava: Is it the healthy substitute for alcohol you have been waiting for? Native to the beautiful South Pacific islands, Kava is a famous beverage rooted in the local culture. It…
How seitan proved to be a blessing in disguise for vegans worldwide Can only meat-eaters enjoy delicious juicy steaks and burgers? With seitan, the best meat substitute available today,even vegans…
Appendix pain: Recent findings on this not-so vestigial organ The exact function of the appendix is still not clear. Some consider it as an organ that once…
Surgery or home-remedy; what is the right way to treat a burn The treatment of a burn injury depends on its severity. You can save a life by offering the…
liver cleanse detox
14 go-to foods that are best for a complete natural liver detox Liver cleanse can be achieved by just choosing or avoiding certain types of food. Liver itself is a detoxifying…
Chest X-Ray A chest x-ray is a diagnostic test that uses x-rays to visualize the structures inside your chest. It…
Strep throat pain
Anti-Streptolysin-O Test The ASO or Anti-Streptolysin-O is a blood test designed to check for the presence of streptococcus bacterial infection…
phenytoin test
Phenytoin test Phenytoin is a drug that is administered mainly to epilepsy patients. The phenytoin blood test measures the level…
AHBC Igm
Anti-Hepatitis B Core Antigen (AHBc) IgM Anti-hepatitis B core antigen (AHBC) IgM is an investigative procedure to detect the presence of IgM antibodies in…
ureteroscopy
Ureteroscopy Ureteroscopy is the diagnostic procedure which is used for the detection of the kidney stones in addition to…
Unbelievable health benefits of gooseberries (and a few tasty recipes) Gooseberries are antioxidant-rich tasty fruits that can be easily added in daily diet to improve overall health and…
Squid-ink-spaghetti
Squid Ink: A unique food coloring and flavoring agent Want to add a unique black color to your pasta, noodles and ice-creams? How can you use squid…
Squid-ink-spaghetti
Squid Ink: A unique food coloring and flavoring agent Want to add a unique black color to your pasta, noodles and ice-creams? How can you use squid…
Squid-ink-spaghetti
Squid Ink: A unique food coloring and flavoring agent Want to add a unique black color to your pasta, noodles and ice-creams? How can you use squid…
piles fissure fistula
Allopathy vs homeopathy vs ayurveda treatment for piles, fissures, and fistula Read to know the best form of treatment among allopathy, homeopathy,or ayurveda for piles, fissures, and fistula
cancer facts
8 hard-hitting truths no one tells you about cancer Did you know that 1.5 million new cases of cancer are reported every year? Can second-hand smoking kill…