Ovarian Cancer

Ovarian cancer teal ribbon

Last Updated December 20th, 2021

Overview

The ovary is a very important part of the reproductive system and is directly involved in the production of eggs and essential sex hormones. Diseases of the ovary may arise at any point of time in the life of a woman, especially in the post-menopausal phase. One common disease of the ovary that is affecting many elderly women all over the world is “Ovarian Cancer”. It has been found to be the eight most common type of cancer in women. According to epidemiological studies by the American Cancer Society, 140,000 fatalities are reported each year (globally) due to ovarian cancer. Therefore it is clear that ovarian cancer has a direct impact on the life expectancy of women all over the world.

 

What is ovarian cancer?

Ovarian cancerOvarian cancer is the medical term for abnormal and uncontrollable cell growth within the ovary that proliferates and spreads to other vital organs with time. In every woman, one of the ovaries is responsible for the production of eggs (ova) and the other ovary is responsible for the production of the sex hormones viz- estrogen and progesterone. Ovarian cancer results due to abnormal growth of any of the three types of cells that constitute the ovary such as- epithelial cells, germ cells, and stromal cells. In most cases, the tumors are benign and do not spread to the neighboring organs. But in a few cases, the tumors are malignant and invade the adjoining tissues and organs causing ovarian cancer.

 

What causes ovarian cancer?

Ovarian cancer may be an outcome of numerous environmental, physiological and psychological factors. The general etiological factors behind ovarian cancer are described below-

  • Age: Ovarian cancer is common in elderly women above 50, in the premenopausal phase due to a sharp decline in the levels of the two essential sex hormones that is, estrogen and progesterone.
  • Obesity: Studies have shown that overweight women, especially the ones having a Body Mass Index (BMI) equal to or above 30 are more prone to ovarian cancer.
  • Childbirth: Women having no children or having children after the age of 35 are more vulnerable to ovarian cancer. These risks are reduced after 1-1.5 years of breastfeeding.
  • Drugs: Prolonged intake of fertility drugs such as clomiphene citrate can increase chances of ovarian cancer in women who fail to get pregnant even after taking these drugs. Also, women taking Danazol which enhances the secretion of androgen hormones might have increased risks of ovarian cancer.
  • Hormonal therapies: Women undergoing hormone replacement therapies (to prevent osteoporosis in post-menopausal phase) are prone to ovarian cancer conditions. These conditions are more prominent in women having only estrogen intake and not progesterone.
  • Heredity: Family history of ovarian cancer can lead to similar diseases in the future generations as well. Mutated variants of the BRCA1 and BRCA2 genes are responsible for inherited ovarian cancer.
  • Existing malignancies: Presence of breast, uterine or colorectal cancer can contribute to ovarian cancer. Endometriosis can also lead to such serious conditions.

 

Symptoms of ovarian cancer

Ovarian cancer scarsOvarian cancer is typically manifested through the following symptoms-

  • Frequent urge to pass urine
  • Vaginal bleeding or other abnormal vaginal discharge in post-menopausal women
  • Feeling of pain and pressure in the lower abdomen and pelvic region
  • Pain radiating from the abdominal region to back
  • Abnormal bloating of the abdomen due to an accumulation of excess fluid (ascites)
  • Loss of appetite and feeling of fullness even after a very small meal
  • Gastrointestinal disorders such as constipation, diarrhea or dyspepsia
  • Painful intercourse
  • Changes in the menstrual cycle in premenstrual women
  • Extreme fatigue and general body ache
  • Breathlessness due to fluid accumulation in lungs (pleural effusion in advanced stages)
  • Bowel obstruction due to a growth of a mass in the abdomen

 

Types of ovarian cancer

Ovarian cancer is classified according to the type of ovarian cell affected. These are described below-

  • Epithelial ovarian tumors: Majority of ovarian tumors belong to this category (85-90%). They originate from the cells that form the outer layer of the ovary. Epithelial ovarian carcinomas may be of serous, mucinous, endometrioid and clear cell types. Epithelial tumors spread to the inner linings of the abdomen and pelvis. Accumulation of excess fluid may result in this condition (ascites) that leads to abdominal swelling.
  • Germ cell ovarian tumors: They constitute about 2% of all ovarian tumors. They have the following subtypes-
  • Teratoma: They are also called dermoid cysts and are made up of tissues similar to the dermis. Immature Teratomas usually generate from connective tissues.
  • Dysgerminoma: It usually affects women in their twenties or teenagers. It is usually cured by complete removal of the ovary.
  • Choriocarcinoma: It usually originates in placenta and in very rare cases starts in the ovary. Few tumors of this category do not respond well to chemotherapy.
  • Stromal cell ovarian carcinoma: Tumours of this category produce excess quantities of estrogen and at times androgen. This leads to vaginal bleeding in many cases.

 

Stages of ovarian cancer

Ovarian cancer passes through the following stages-

  • Stage I: Tumours are present on the ovarian surface or within the accumulated abdominal fluid.
  • Stage II: Tumours spread to the tissues of the fallopian tubes and uterus.
  • Stage III: Tumours spread to the omentum (fatty tissues hanging from colon and stomach), diaphragm, intestine and the outer surface of the liver.
  • Stage IV: Cancerous cells spread to the liver, lungs, and spleen.

 

Diagnosis

The following diagnostic tests are usually recommended for proper treatment of ovarian cancers-

  • MRI scans to detect abnormal pelvic masses
  • Ultrasound of ovaries to detect solid tumors or fluid-filled cysts
  • CT scans to detect the spread of tumors to other organs, especially the lymph nodes
  • Laparoscopy to detect stage of cancer
  • Biopsy (performed after any of the previous tests give positive results)
  • Blood tests

 

Treatment and prevention

Treatment 

Ovarian cancer teal ribbonSurgery 

  • Surgical methods to treat the early stages of ovarian cancer will include removing one ovary and the fallopian tube.
  • In case cancer has spread to both the ovaries and not the abdomen; both the ovaries and the fallopian tubes will be removed, leaving the uterus intact.
  • If it is a severe case of ovarian cancer, both the ovaries, fallopian tubes and the uterus will be removed.
  • Doctors may recommend chemotherapy followed by surgery to try to remove the cancer cells completely.

Chemotherapy – Here, cancer-killing drugs are given orally or intravenously to the patient to help treat cancer.

Targeted therapy – The weak link among the cancer cells are targeted here to help treat ovarian cancer.

Palliative (supportive) care –Those who have been diagnosed with ovarian cancer, will be recommended to undergo palliative care to help them cope with the condition and the treatment side effects.

Prevention 

  • Consult healthcare specialists before taking oral contraception. Though oral contraception is known to reduce the risks of ovarian cancer, they have their side effects too.
  • Go for a routine gynecological check-up.
  • Do not indulge in smoking, as it is one of the leading causes of ovarian cancer.
  • Maintain extra care from these risk factors if you have a family history of ovarian cancer.

 

  1. https://ovariancancer.gog199.cancer.gov/
  2. https://www.nih.gov/news-events/news-releases/nih-study-finds-regular-aspirin-use-may-reduce-ovarian-cancer-risk
  3. https://www.ncbi.nlm.nih.gov/pubmed/29205312
  4. https://canceraustralia.gov.au/
  5. https://www.cdc.gov/cancer/ovarian/statistics/index.htm

 

 

Facts

  • More than 14o,000 American women die due to ovarian cancer every year.
  • It is one of the deadliest gynecological diseases.
  • There are more than 30 types of ovarian cancers.

Facts

  • If ovarian cancer is detected in its early stages (stage 1 and 2) there are 70-75% chances of treating the condition.
  • Ovarian cancer is the 5th deadliest cancer among women.

Facts

  • Genes linked to breast cancer tend to increase the chances of ovarian cancer.

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Dos and Don'ts

Dos
  • Reduce your stress levels and keep your mind calm and clean. This helps in making sure that other medical conditions do not arise or aggravate. Stress is also known to decrease the effectiveness of the immune system.
  • Join a support group to help cope with the treatment and condition.
Don'ts
  • Consume unhealthy foods such as oily, refined and processed food.
  • Indulge in smoking; it is a leading cause of many illnesses and cancers.
  • Indulge in illicit sex; those who have multiple sexual partners are at a higher risk of developing sexually transmitted diseases.

 

 

 

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What are Shiitake Mushrooms and why should you eat them? Shiitake Mushrooms are well known for their smoky and robust taste. However, did you know they are replete…
pilonidal sinus
Pilonidal sinus Pilonidal sinus is more common in young men than women. Learn about treatment options, surgical management, risks, and…
improve digestion weight loss
Power up your gut: 8 proven steps on how to improve your digestion Did you know you have a colony of bacteria in your gut that help you in digesting food?…
low fodmap plan
Troubled with IBS? Here’s a complete roadmap to the low FODMAP diet Leaky & inflammatory gut troubling you? No medicine bringing you relief from the pain? Why not try the…
Kava: Is it the healthy substitute for alcohol you have been waiting for? Native to the beautiful South Pacific islands, Kava is a famous beverage rooted in the local culture. It…
Psyllium Husk: More than just an effective natural laxative Psyllium husk, or isabgol, is a popular natural laxative . But did you in addition to regulating bowels,…
Find all the instant ways to get rid of blackheads Blackheads - Not only are they aesthetically unappealing but if left untreated these can cause bacterial overgrowth on…
Ear pain model
Easy and safe tips for ear wax removal you can do at home Cerumen impaction generally occurs when an external object like cotton swabs are used to remove the ear wax.…
Atkins diet weight loss
Atkins Diet: The right steps to carb control that can help you lose those pounds fast The Atkins diet is a high fat, low-carb diet with proven weight loss benefits that is flexible enough…
Chest X-Ray A chest x-ray is a diagnostic test that uses x-rays to visualize the structures inside your chest. It…
blood elements analysis
Blood Element Analysis Test A blood element analysis is a blood test performed to measure the level of toxic elements such as…
PROGESTERONE_test
Progesterone test The progesterone test is a blood test used to determine the level of hormone progesterone in the blood…
iron deficiency profile
Iron Deficiency Profile An iron deficiency profile is a battery of blood tests which are performed in order to determine the…
Okra: How can this nutrient-dense vegetable help you fight diabetes? Okra is a food which is rich in nutrients and minerals which are extremely essential for a healthy…
dance health benefits
5 unbelievable effects of dance on your overall health! You enjoy dancing, but did you know what else it does to your body? Dancing is not only…
Jack in the box fast food
Jack In the Box : The perils of surging fast food culture in the USA Jack in the Box - How a culture of fast-food can clog your arteries, weaken your heart, fatten…
black seed oil benefits
Black Seed Oil: What secret benefits could it bestow on your health? Black seeds or nigella seeds are tiny packets of health brimming with amazing benefits. Find out why should…
Oil of Oregano: The one-stop essential oil you’ve been looking for Are you plagued by a weak immune system? High body inflammation accompanied by pain and infections? Why not…
Epley maneuver: Why is this the best protection from the symptoms of vertigo? Epley maneuver is an exercise that can treat the symptoms of benign paroxysmal positional vertigo (BPPV).  It was…
Tart Cherry: The healthiest excuse for taking that second serving of pie Tart cherry has been traditionally used in delectable desserts such as pies. Recent studies have revealed that its…
Hydroquinone: Is it the best topical treatment for hyperpigmentation? Darkening of the skin due to high melanin levels is called hyperpigmentation.  Hydroquinone interferes with melanin production thus treating…
Inversion Therapy: The anti-gravity way of healing chronic back pain Inversion therapy involves suspending a person upside dow using different types of equipment. This works by taking the…
The Cabbage Soup Diet: The healthiest way to instant weight loss Cabbage soup diet rapid weight loss diet for those who want to shed those extra pounds in less…
Coffee Enema: Turn your favorite morning beverage into a powerful colon cleanser The wonders of coffee are not just limited to waking you up every morning. You can now use…
CBC blood test
CBC (Hemogram 6-part diff) blood test CBC (Hemogram 6-part diff) blood test refers to the test that measures the number of RBCs, WBCs, etc…
reflexology massage
Top reasons why you should go for a reflexology massage today Reflexology involves the application of pressure to your feet and hands to encourage self-healing. Could this be beneficial…
Bone marrow aspiration Bone marrow aspiration is a process where a sample of the bone marrow is withdrawn from the bone…
C-Reactive Protein Test A CRP or c-reactive protein blood test is an important diagnostic tool used to determine the risk of…
HSV-1_IGG
Herpes Simplex Virus I (HSV)-IgG Test Herpes simplex virus I(HSV)-IgG is an Immunoglobulin protein that acts as an antibody & stays in the blood…
malarial antigen test
Malaria Antigen Test A malaria antigen test is a rapid diagnostic test (RDT) that can detect malarial antigens (proteins) in your…
lipase test
Lipase Test A lipase test is a blood test performed to quantitatively measure the level of the enzyme lipase in…
Squid-ink-spaghetti
Squid Ink: A unique food coloring and flavoring agent Want to add a unique black color to your pasta, noodles and ice-creams? How can you use squid…
Squid-ink-spaghetti
Squid Ink: A unique food coloring and flavoring agent Want to add a unique black color to your pasta, noodles and ice-creams? How can you use squid…
Squid-ink-spaghetti
Squid Ink: A unique food coloring and flavoring agent Want to add a unique black color to your pasta, noodles and ice-creams? How can you use squid…
Sushi: health benefits and recipes Sushi is a traditional Japanese dish prepared with vinegared rice served with fish (often raw), vegetables, and other…
hidden benefits walking
9 benefits of walking we bet you didn’t know! Did you know walking can be the miracle pill for eternal youth? Everyone knows walking is good for…