Leukocytosis

Leukocytosis and skin infections

Last Updated August 23rd, 2019

Leukocytosis is the condition where the number of WBC in the blood increase beyond a given threshold. This is generally the body’s response to an infection or inflammation. However, the increase in leukocyte count can also occur as a result of malignancy or cancer onset. When the symptoms of leukocytosis are severe, they can increase the thickness of the blood to the extent that it doesn't circulate normally. Pregnancy can also cause the WBC count to become high.
The early signs and symptoms of leukocytosis are fever and pain at the site of infection. People tend to get bruised easily, experience sudden weight loss, and even have night sweats. There might be skin rashes or hives all over the skin. Many experience difficulty in breathing and wheezing, similar to that of an allergic reaction.
Leukocytosis is defined as the condition where the WBC count of the blood is extremely high. WBC or white blood cells form your body’s immune system. Anytime there is an infection or inflammation, these are dispatched to the said location in the body to fight the microbes. There are 5 different types of WBCS- monocytes, lymphocytes, neutrophiles, basophils, and eosinophils. Increase in the count in any of these results in leukocytosis.
Neutrophils are a component of the WBCs. Around half of all WBCs are ,in fact, neutrophils. These cells can travel freely to any part of the body, unlike other components of WBCs which have some restrictions. They can even enter the veins and attack disease-causing pathogens.

Overview of leukocytosis

Human blood is formed of different components, of which red blood cells (RBC), white blood cells (WBC) and platelets are the most important ones. Alterations in the count of any of these may lead to diseases that are not easily curable. Past incidences have shown that some of these diseases may even progress to cancer. Leukocytosis is one such disease where the white blood cell count is abnormally high. Anyone type of white blood cell may rise in number under this condition. In future, it may even result in a type of malignancy which is known as Leukaemia.

 

What is leukocytosis?

Leukocytosis WBCsIn medical terms, leukocytosis is a rise in the number of leukocytes or white blood cells much above the normal value. In the moderate conditions, it is simply an inflammatory response to an infection. Any of the five types of leukocytes namely- neutrophil, lymphocyte, monocyte, eosinophil, and basophil can increase in number in this medical condition. A left upper shift in the ratio of immature to mature neutrophils and macrophages occurs mainly when the neutrophil count rises. On the other hand, a reduced count of the newly formed neutrophils (metamyelocytes) is referred to as a right shift in the ratio of immature to mature neutrophils. A leukocyte count of above 25-30 x 109 / L is observed on a blood smear test.

 

What causes leukocytosis?

Leukocytosis mainly results from serious infections, though there can be other factors as well. The general factors are listed below-

  • DNA damage: Destruction or mutation of DNA of White Blood Cells due to various factors cause activation of oncogenes (cancerous genes) and deactivation of tumor suppressor genes (cancer-preventing genes) and lead to a rise in WBC.
  • Radiation: Unprotected exposure to harmful radiations (ionizing or non-ionizing) during different diagnostic tests such as imaging, or radiotherapy to treat existing diseases can lead to leukocyte imbalance in future.
  • Chemicals: Toxicity induced by certain chemicals such as benzene, mercury, cadmium etc can cause a rise in WBC count in patients who are exposed to these chemicals on a regular basis (due to occupational hazards).
  • Viral infections: Past infection with Human T-cell Lymphoma Virus-1 (HTLV-1) can cause lymphocytic leukemia.
  • Heredity: Certain inherited syndromes such as Down syndrome, Klinefelter syndrome or Neurofibromatosis can predispose an individual to Leukocytosis.
  • Auto-immune disorders: Immune suppression can lead to abnormal cell growth within the body, increasing the risks of Leukocytosis.
  • Blood disorders: Certain blood diseases such as Thrombocythemia and Myelofibrosis increase the possibilities of Acute Myeloid Leukemia.
  • Substance abuse: Addictive habits like excessive cigarette smoking or alcoholism can damage different organs of the body leading to Leukocytosis.

Leukocytosis and infectionsSome other causes of the disease may include

  • Bone tumors
  • Rigorous exercise
  • Mental and physical stress
  • Epileptic fits
  • Epinephrine administration
  • Pregnancy and labor
  • Anesthesia
  • Exposure to electromagnetic radiation (due to proximity to power grids)
  • Direct contact with harmful chemicals such as diesel, gasoline or pesticides

 

What are the warning signs and symptoms?

Leukocytosis generally presents with the following symptoms-

  • Abdominal swelling due to aggregation of white blood cells in the spleen and liver
  • Swollen lymph nodes due to spread of cancerous cells in those regions
  • Acute joint pain due to an accumulation of leukocytes on the bone surface
  • Shortness of breath due to spread of white blood cells to the lungs and bronchi
  • A headache, fatigue, seizures, nausea, vomiting, vision impairment and overall body imbalance due to an intrusion of the abnormal white blood cells into the Central Nervous System
  • Frequent bleeding from the nose and gums
  • Frequent bruising which takes a long time to heal
  • Perspirations at night
  • Fever and general body ache
  • Loss of appetite and abnormal weight loss
  • Persistent infections
  • Minute reddish spots under the skin
  • Abnormal hair loss

What are the different types of leukocytosis?

Based on which leukocyte is affected, the disease is categorized into five types-

Neutrophilia: It is marked by an increase in the count of neutrophil granulocytes in the blood. This condition may arise from-

  • Serious bacterial infections (pyogenic infections)
  • Sterile inflammation (tissue necrosis, myocardial infarctions, burns)

Eosinophilia: In this condition, the eosinophil count in the blood (peripheral blood) rises above 4.5 x 108/L. The main causes are-

  • Allergic disorders (Asthma, Hay fever, Drug allergies, Pemphigus, Dermatitis)
  • Eosinophilic esophagitis or gastroenteritis
  • Malignancies (Leukaemia, Hodgkin’s and non-Hodgkin’s lymphoma)
  • Cholesterol embolism

Basophilia: This is a condition marked by an increase in the count of basophil in the blood (more than 1010 basophils per liter of blood). Constant itching (Pruritis) occurs due to the release of histamine.

Monocytosis: The number of monocytes in the blood rises above 950 / µL. The main causes of monocytosis are-

Lymphocytosis: As implied by the name, it is an increase in the count of lymphocytes in the circulating bloodstream. A lymphocyte count greater than 4000/ µL (in adults) and 7000 / µL in children indicates Lymphocytosis.

 

Diagnostic Tests

The patients are advised to get the following diagnostic tests done-

  • Blood tests (complete blood count and coagulation tests)
  • Bone marrow tests (bone marrow aspiration and biopsy)
  • Chromosome testing (to detect chromosomal aberrations)
  • Lumbar puncture (to detect the spread of cancer cells into the brain and spinal cord)
  • Lymph node biopsy
  • Imaging tests ( X-rays, CT scan, MRI scan)

 

Treatment and Prevention

Leukocytosis and skin infectionsThe treatment of leukocytosis is administered through:

  • IV fluids which replenish electrolytes
  • Medications usually comprising of antibiotics and steroids to reduce inflammation.
  • Complete or partial blood transfusion
  • Reduction of leukocytes
  • Bone marrow transplant

There are several healthy lifestyle habits that can reduce your risk of developing leukocytosis. These include:

  • Negligible or no alcohol consumption.
  • Avoiding reheating of food in a microwave oven.
  • Reduction in refined sugar consumption in the form of processed foods and aerated drinks.
  • Consuming a diet rich in antioxidants and vitamin C.

 

 

Facts

  • Certain medications which are used in the treatment of inflammations, mental disorders, respiratory issues, or cancer can cause the WBC count to surge.
  • The process used to decrease the WBC count is known is leukapheresis. In this, the blood is drawn from IV, WBCs are removed, and then the blood is again supplied back to the patient.

Facts

  • WBCs make up only 1% of our bloodstream. Our body produces 100 billion WBCs every day.
  • A healthy adult should have 4,000-11,000 WBC count/ mL of blood.

Facts

  • There are 5 types of WBCs – monocytes, lymphocytes, neutrophils, basophils, and eosinophils.
  • If an adult has more than 30,000 WBC count in 1 cc. of blood, it may be indicative of leukemia or blood cancer.

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Leukocytosis is the condition where the number of WBC in the blood increase beyond a given threshold. This is generally the body’s response to an infection or inflammation. However, the increase in leukocyte count can also occur as a result of malignancy or cancer onset. When the symptoms of leukocytosis are severe, they can increase the thickness of the blood to the extent that it doesn't circulate normally. Pregnancy can also cause the WBC count to become high.
The early signs and symptoms of leukocytosis are fever and pain at the site of infection. People tend to get bruised easily, experience sudden weight loss, and even have night sweats. There might be skin rashes or hives all over the skin. Many experience difficulty in breathing and wheezing, similar to that of an allergic reaction.
Leukocytosis is defined as the condition where the WBC count of the blood is extremely high. WBC or white blood cells form your body’s immune system. Anytime there is an infection or inflammation, these are dispatched to the said location in the body to fight the microbes. There are 5 different types of WBCS- monocytes, lymphocytes, neutrophiles, basophils, and eosinophils. Increase in the count in any of these results in leukocytosis.
Neutrophils are a component of the WBCs. Around half of all WBCs are ,in fact, neutrophils. These cells can travel freely to any part of the body, unlike other components of WBCs which have some restrictions. They can even enter the veins and attack disease-causing pathogens.

 

Dos and Don'ts

Dos
  • Anti-oxidant rich food, i.e, foods containing vitamin C and E are best for controlling WBC counts in leukocytosis patients.
  • Consume more of mono-unsaturated fats and foods low on glycemic index.
  • If a person with leukocytosis experiences sudden weight loss, persistent nausea, or a high-grade fever, he/she should visit the doctor immediately.
Don'ts
  • Go for a blood test for checking the WBC count just after performing physical exercises. Exercising increases WBC count.
  • Expose yourself to specific allergens (dust, pollen etc) because allergic reactions cause the WBCs to increase rapidly.
  • Consume dairy products, packaged and processed goods, alcohol, and artificial sweeteners.

 

 

 

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Serotonin: What you didn’t know about this “feel-good” chemical Serotonin : Did you know that this "feel-good" hormone could well impact your sleep cycle, sex drive, appetite,…
improve digestion weight loss
Power up your gut: 8 proven steps on how to improve your digestion Did you know you have a colony of bacteria in your gut that help you in digesting food?…
Coconut sugar: What is it and is it healthier than table sugar? In the long list of things that the wonderful coconut gives us, coconut sugar is another remarkable addition.…
10 reasons why you should up your selenium intake Selenium, though a trace mineral, is very much integral to your health. Find out how much selenium intake…
waterchestnut
Water Chestnuts: The tastiest ways to include this healthy tuber in your diet Water chestnut is not a nut after all. It is a tuber (much like the potatoes) growing close…
General adaptation syndrome: Understanding stress, one step at a time The struggle of the body to produce hormones during a stressful situation is the main theme of general…
Quinine: How gin and tonic came to be known as a potent health elixir The discovery of quinine-containing tree bark is sometimes considered the most serendipitous medical discovery of the 17th century.
How to scrub away stress and fatigue with an Epsom salt bath? Epsom salt is a popular home remedy for many skin ailments. Though there is a lack of scientific…
These are the top foods to increase your hemoglobin count It is important to add iron-rich foods into your diet in order to increase hemoglobin. Deficiency of hemoglobin could…
liver cleanse detox
14 go-to foods that are best for a complete natural liver detox Liver cleanse can be achieved by just choosing or avoiding certain types of food. Liver itself is a detoxifying…